|Table of Contents|

Research progress of NOTCH signaling pathway in oral cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 06
Page:
1162-1165
Research Field:
Publishing date:

Info

Title:
Research progress of NOTCH signaling pathway in oral cancer
Author(s):
XIONG Xiaoxue1; LIAO Chengcheng1; 2; 3; LIU Jianguo1; 2; XIANG Mingli1; GUO Qiushuang1; LONG Sicen1; YUE Chaoyi4; GUAN Xiaoyan1; 2
1.Affiliated Stomatological Hospital of Zunyi Medical University,Guizhou Zunyi 563000,China;2.Guizhou Provincial Key Laboratory of Oral Disease Research in Colleges and Universities,Guizhou Zunyi 563000,China;3.West China School of Stomatology,Sichuan University,Sichuan Chengdu 610000,China;4.School of Medicine and Science,Zunyi Medical University,Guizhou Zunyi 563000,China.
Keywords:
NOTCH signaling pathway; oral squamous cell carcinoma; cancer stem cells; epithelial-mesenchymal transition
PACS:
R739.8
DOI:
10.3969/j.issn.1672-4992.2023.06.036
Abstract:
The NOTCH signaling pathway is a conserved molecular pathway that is essential for tissue homeostasis.Oral squamous cell carcinoma (OSCC) is one of the most common solid tumors,and changes in its NOTCH signaling pathway promote biological malignant behaviors such as tumor cell proliferation,migration,and drug resistance.In this review,the NOTCH signaling pathway is involved in key tumorigenic events in OSCC,including regulation of abnormal angiogenesis,tumor stem cell turnover,and epithelial-mesenchymal transition.Therefore,the NOTCH signaling pathway may be a key molecular signal regulating OSCC formation and provide a promising therapeutic target for OSCC targeted therapy.

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Memo

Memo:
国家重点研发计划项目（编号：2016YFC1102800）；National Natural Science Foundation of China(No.82060205); 国家自然科学基金项目（编号：82060205）；贵州省医用生物材料研发人才基地项目（编号：黔人领发［2018］3号）；贵州省普通高等学校青年科技人才成长项目（编号：黔教合KY字［2021］215）
Last Update: 1900-01-01