|Table of Contents|

The gain value of thyroglobulin in predicting cervical lymph node metastasis in papillary thyroid carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 06
Page:
1043-1046
Research Field:
Publishing date:

Info

Title:
The gain value of thyroglobulin in predicting cervical lymph node metastasis in papillary thyroid carcinoma
Author(s):
HE Wei; WEI Guangming; WANG Lei; SUN Tao; WANG Junyan; LI Yunbo; YUAN Menghui; WEI Longxiao
Department of Nuclear Medicine,the Second Affliated Hospital of Air Force Medical University,Shaanxi Xi'an 710038,China.
Keywords:
thyroglobulin; papillary thyroid carcinoma; lymph node metastasis
PACS:
R736.1
DOI:
10.3969/j.issn.1672-4992.2023.06.011
Abstract:
Objective：Rearching the clinical effectiveness of thyroglobulin (Tg) prediction of cervical lymph node metastasis of papillary thyroid carcinoma(PTC).Methods:218 PTC patients who underwent removing residual thyroid tissue were included in the study.Patients were divided into no lymph node metastasis group,a lymph node metastasis group,two pieces of lymph node metastasis group and more than two lymph node metastasis group,according to the whole body 131I scanning.We compared the differences between each group,and analyzed the differences and correlations of serum Tg value in each group.The maximum diagnostic efficiency of serum Tg was detected by ROC curve.Results:There was difference in serum Tg value between the group without lymph node metastasis and the group with lymph node metastasis (P＜0.05).There was no statistical difference in Tg between groups with different number of lymph node metastasis (P＞0.05) and serum Tg value had no correlation with the number of lymph node metastasis (P＞0.05).Further,the sensitivity,specificity,accuracy of the diagnosis of lymph node metastasis were 68%,80%,72% when Tg was 1.5 ng/mL,meanwhile the area under ROC curve reached the maximum 0.77.Conclusion:Serum Tg value has certain clinical value in determining the possibility of lymph node metastasis postoperative TPC,but the number and degree of metastasis cannot be determined according to its level.The recommended cutoff for predicting the diagnostic efficacy of lymph node metastasis after removing residual thyroid tissue is 1.5 ng/mL.

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