|Table of Contents|

Correlation between the cytokine levels before and after chemotherapy and involved chemotherapy-induced cognitive impairment in non-Hodgkin' s lymphoma patients

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 04
Page:
733-736
Research Field:
Publishing date:

Info

Title:
Correlation between the cytokine levels before and after chemotherapy and involved chemotherapy-induced cognitive impairment in non-Hodgkin' s lymphoma patients
Author(s):
LI Haowu; CHENG Huaidong; XUAN Han
Department of Oncology,the Second Affiliated Hospital of Anhui Medical University，Anhui Hefei 230000,China.
Keywords:
non-Hodgkin's lymphoma; chemotherapy-induced cognitive impairment; cytokines; KPS
PACS:
R733.4
DOI:
10.3969/j.issn.1672-4992.2023.04.026
Abstract:
Objective:To investigate,the changes of cytokine levels and cognitive function in patients with non-Hodgkin's lymphoma(NHL)before and after chemotherapy to clarify the correlation between cytokines,functional status and cognitive function.Methods:A total of 30 patients with NHL were included in this study.These patients completed cognitive assessment and cytokine levels which including interleukin 4（IL-4） and interleukin 6（IL-6） before chemotherapy and after 2 courses of chemotherapy.Results:The IL-4 level of patients was higher before treatment than after treatment（t=2.85,P<0.01）,and IL-6 level was lower before treatment than after treatment（P<0.01）.IL-6 had a weak correlation with retrospective memory(RM) and prospective memory(PM)(r=0.282 and 0.270,respectively,all P<0.05).There was a moderate correlation between IL-6 and ECog-12(r=0.314,P<0.05),but no statistical association was found between cognition and IL-4.There was a moderate correlation between subjects' cognition(MMSE,VFT,SDMT,CDT,RM)and KPS(r=0.479,0.378,0.464,0.396 and-0.366,respectively,all P<0.01).Conclusion:The cognitive function of NHL patients is impaired in a short time after chemotherapy,which is manifested in visuospatial disturbance,language and memory.IL-4 may be a protective factor of cognitive function,and IL-6 may be a factor of impairment of cognitive function.Management and improvement of cognitive function in NHL will help to improve KPS levels.

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Memo

Memo:
National Natural Science Foundation of China(No.81872504);国家自然科学基金资助项目（编号：81872504）
Last Update: 1900-01-01