|Table of Contents|

Expression and clinical significance of ITGA5 in glioma tissues

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 04
Page:
648-652
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of ITGA5 in glioma tissues
Author(s):
MENG Xianglong1; 2; ZHANG Moxuan3; WANG Mingguang2; SUN Qiang1; XUE Zhengchun1; DU Fei1; FU Jidi4
1.Weifang Medical University,Shandong Weifang 261053,China;2.Department of Neurosurgery,Linyi People's Hospital,Shandong Linyi 276000,China;3.Capital Medical University,Beijing Institute of Neurosurgery,Beijing 100070,China;4.Department of Neurosurgery,Plastic Surgery Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100026,China.
Keywords:
glioma; ITGA5; clinicopathology; prognosis
PACS:
R730.264
DOI:
10.3969/j.issn.1672-4992.2023.04.010
Abstract:
Objective:To investigate the expression of integrin α5 (ITGA5) in glioma tissues and its relationship with clinicopathological parameters and prognosis.Methods:Comparing the differences in the expression of ITGA5 and the biological information of clinical prognosis in glioma and normal brain tissues in the TCGA database.Collecting the glioma tissue specimens and clinical data of 54 patients with glioma surgery in Linyi People's Hospital,and the brain tissue specimens of 20 patients with traumatic brain injury after intracranial decompression.The brain tissue after trauma was used as the control,and the expression of ITGA5 protein in glioma was detected by immunohistochemical staining and western blotting.Statistical methods were used to study the correlation between ITGA5 expression level and clinicopathological parameters.By drawing survival curves,the difference in prognosis of patients with high and low expression of ITGA5 was compared.Results:In the TCGA database,the expression of ITGA5 in LGG and GBM was significantly different (P＜0.001),and the expression increased with the increase of the WHO pathological grade of glioma,and was related to the poor prognosis of patients.The high expression rate of ITGA5 in glioma tissue was 59.2%(32/54),and the high expression rate in brain tissue after trauma was 5.0%(1/20),and the difference was statistically significant (P＜0.05).The expression of ITGA5 in glioma tissue was correlated with WHO grade,Ki-67 and p53 genotype (P＜0.05),but not with age,gender and tumor site (P＞0.05).The survival time of patients with gliomas with high ITGA5 expression was significantly lower than that of patients with gliomas with low ITGA5 expression (P＜0.05).Conclusion:The expression of ITGA5 is increased in glioma tissue,and the expression of ITGA5 is closely related to the pathological grade of glioma and the survival of patients.

References:

［1］XU SC,TANG L,LI XZ,et al.Immunotherapy for glioma:Current management and future application［J］.Cancer Lett,2020,476:1-12.
［2］ MIYAUCHI JT,TSIRKA SE.Advances in immunotherapeutic research for glioma therapy［J］.J Neurol,2018,265(4):741-756.
［3］ GUO XR,WANG T,HUANG GH,et al.Rediscovering potential molecular targets for glioma therapy through the analysis of the cell of origin,microenvironment and metabolism［J］.Curr Cancer Drug Targets,2021,21(7):558-574.
［4］CAO L，CHEN Y，ZHANG M，et al.Identification of hub genes and potential molecular mechanisms in gastric cancer by integrated bioinformatics analysis［J］.PeerJ,2018,6:e5180.
［5］XIAO YJ,LI YF,TAO H,et al.Integrin alpha5 down-regulation by miR-205 suppresses triple negative breast cancer stemness and metastasis by inhibiting the Src/Vav2/Rac1 pathway［J］.Cancer Lett,2018,433:199-209.
［6］GAO QL，YANG ZY，XU S，et al.Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer［J］.J Exp Med,2019,216（3）:688-703.
［7］国家卫生健康委员会医政医管局.脑胶质瘤诊疗规范(2018年版) ［J］.中华神经外科杂志,2019,35 (3):217-239. Medical Administration and Hospital Administration of the National Health Commission.Guidelines for the diagnosis and treatment of glioma (2018 edition) ［J］.Chinese Journal of Neurosurgery,2019,35(3):217-239.
［8］LUDWIG K,KORNBLUM HI.Molecular markers in glioma［J］.J Neurooncol,2017,134(3):505-512.
［9］ DUNN GP,CLOUGHESY TF,MAUS MV,et al.Emerging immunotherapies for malignant glioma:from immunogenomics to cell therapy［J］.Neuro Oncol,2020,22(10):1425-1438.
［10］HASHIZUME R.Epigenetic targeted therapy for diffuse intrinsic pontine glioma［J］.Neurol Med Chir (Tokyo),2017,57(7):331-342.
［11］ HOU JB,YAN D,LIU YD,et al.The roles of integrin α5β1 in human cancer［J］.Onco Targets Ther,2020,13:13329-13344.
［12］ KARAKAS N,KILIC U.Integrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiation［J］.In Vivo,2021,35(4):2127-2134.
［13］ ZHU H,CHEN A,LI SS,et al.Predictive role of galectin-1 and integrin α5β1 in cisplatin-based neoadjuvant chemotherapy of bulky squamous cervical cancer［J］.Biosci Rep,2017,37(5):BSR20170958.
［14］ FUJITA M,YAMAMOTO T,IYODA T,et al.Aggressive progression in glioblastoma cells through potentiated activation of integrin α5β1 by the tenascin-c-derived peptide TNIIIA2［J］.Mol Cancer Ther,2019,18(9):1649-1658.
［15］GUO YM,XU GX,SHAN MH,et al.Integrin α5 silencing inhibits proliferation,invasion and metastasis of human liver cancer Bel-7404 cells in vitro［J］.J Southern Medical University,2020,40(6):893-898.
［16］ PANTANO F,CROSET M,DRIOUCH K,et al.Integrin alpha5 in human breast cancer is a mediator of bone metastasis and a therapeutic target for the treatment of osteolytic lesions［J］.Oncogene,2021,40(7):1284-1299.
［17］YU M,CHU ST,FEI BY,et al.O-GlcNAcylation of ITGA5 facilitates the occurrence and development of colorectal cancer［J］.Exp Cell Res,2019,382(2):111464.
［18］KUNINTY PR,BANSAL R,DE GEUS SWL,et al.ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer［J］.Sci Adv,2019,5(9):eaax2770.
［19］LAFAUY P,SILAPECH A,AKSORN N,et al.Millettocalyxin B inhibits migratory behavior of lung cancer cells via integrin α5 suppression［J］.Anticancer Res,2021,41(8):3843-3849.
［20］DENG Y,WAN Q,YAN W.Integrin α5/ITGA5 promotes the proliferation,migration,invasion and progression of oral squamous carcinoma by epithelial-mesenchymal transition［J］.Cancer Manag Res,2019,11:9609-9620.
［21］YAO HB,SHAO QS,SHAO YF,et al.Integrin α5 promotes the proliferation,invasion and adhesion of gastric cancer by regulating the FAK/Src/Rac1 signaling pathway［J］.Chin Med J,2021,01(34):2692-2697.
［22］ VILLEGAS-PINEDA JC,TOLEDO-LEYVA A,OSORIO-TRUJILLO JC,et al.The translational blocking of α5 and α6 integrin subunits affects migration and invasion,and increases sensitivity to carboplatin of SKOV-3 ovarian cancer cell line［J］.Exp Cell Res,2017,351(2):127-134.

Memo

Memo:
山东省医药卫生科技发展计划项目（编号：202104040538）；山东省临沂市科技发展计划项目（编号：202120064）
Last Update: 1900-01-01