|Table of Contents|

Effects of miR-769 on proliferation,invasion,migration and paclitaxel resistance of esophageal squamous cell carcinoma cells

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 03
Page:
428-434
Research Field:
Publishing date:

Info

Title:
Effects of miR-769 on proliferation,invasion,migration and paclitaxel resistance of esophageal squamous cell carcinoma cells
Author(s):
SUN Zhiguang1; HU Tingting1; LU Hongling1; ZHANG Shaowei2; ZHANG Nan2; WANG Jindong1
1.Department of Cardiothoracic Surgery,Cangzhou Hospital of Integrated TCM-WM,Hebei Cangzhou 061013,China;2.Department of Thoracic Surgery,the Fourth Hospital of Hebei Medical University,Hebei Shijiazhuang 050011,China.
Keywords:
esophageal carcinoma; squamous cell carcinoma; paclitaxel resistance; noncoding RNA; epithelial mesenchymal transformation
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2023.03.007
Abstract:
Objective:To investigate the hsa-miR-769（miR-769） expression in esophageal squamous cell carcinoma and its effect on the proliferation,invasion,migration and paclitaxel resistance of cancer cells.Methods:Through bioinformatics technology mining,we conducted an in-depth study on the expression of tumor-associated hsa-miR-769(miR-769),and further verified clinical samples,and further explored its mechanism of action through cell biology and molecular biology studies.Results:The mining results of public database showed that miR-769 expression was abnormally elevated in esophageal carcinoma tissues,and the same abnormal expression was observed in clinical samples.Through cell experiments and molecular biology experiments,we found that miR-769 regulated the proliferation of tumor cells invasion and migration ability can also cause changes in the epithelial mesenchymal transformation process of tumor cells.In subsequent studies,we successfully constructed a paclitaxel-resistant esophageal squamous cell carcinoma line,and found that miR-769 played an important role in the acquired resistance of esophageal squamous cell carcinoma to paclitaxel.Conclusion:miR-769 affect the proliferation,invasion,migration and resistance to paclitaxel of esophageal squamous cell carcinoma.This study aims to explore the mechanism of the occurrence and development of esophageal squamous cell carcinoma,and provide a new potential target for targeted therapy of esophageal squamous cell carcinoma.

References:

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河北省医学科学研究课题计划(编号:20210984)
Last Update: 2022-12-30