|Table of Contents|

Application of the combined detection of tumor markers with NLR in the diagnosis of lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2023 01
Page:
81-85
Research Field:
Publishing date:

Info

Title:
Application of the combined detection of tumor markers with NLR in the diagnosis of lung cancer
Author(s):
LIN Fan1; ZHANG Huan2; WANG Zhuocai3
1.Department of Gastroenterology;2.Department of Radiotherapy;3.Department of Pathology,General Hospital of Southern Theater Command,Guangdong Guangzhou 510010,China.
Keywords:
lung cancer; tumor markers; neutrophil/lymphocyte ratio; combined detection
PACS:
R734.5
DOI:
10.3969/j.issn.1672-4992.2023.01.014
Abstract:
Objective:To investigate the effect of NLR and tumor markers ProGRP,SCCA,CYFRA21-1 and NSE combined detection in the diagnosis of lung cancer.Methods:A retrospective study was performed to collect 134 patients who had been diagnosed with lung cancer in cardiothoracic surgery admitted to our hospital between January 02,2019 to December 23,2019 as the lung cancer group,and another 80 benign cases diagnosed during the same period were selected as control group.Clinical data of the above patients were collected,and the diagnostic value of each index alone or in combination in the diagnosis of lung cancer was retrospectively analyzed by t test and ROC data analysis methods.Results:Serum ProGRP in patients with lung cancer was correlated with age(P＜0.05),SCCA was corrlated with age,lymph node metastasis(P＜0.05) and gender(P＜0.01),Cyfra21-1 was associated with tumor stage(P＜0.05) and NSE was associated with tumor size(P＜0.01) and lymph node metastasis(P＜0.05).NLR was associated with age and degree of tumor differentiation(P＜0.05),and the tumor markers and NLR in lung cancer group were higher than those in control group.The cut-off of each index were determined according to the ROC curve and Youden index,and the areas under the ROC curve were further grouped according to the critical values.The AUC values of the four tumor markers were 0.647,0.615,0.606 and 0.58,respectively,which were lower than that of the combination of those tumor markers with NLR.Conclusion:Preoperative tumor markers and NLR in peripheral blood of patients with lung cancer are higher than those in the control group.NLR in peripheral blood is related to the degree of tumor differentiation，and combined detection of tumor markers with NLR can improve the diagnostic value in lung cancer.

References:

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Memo

Memo:
广州产学研协同创新重大专项基金（编号：201704020157）
Last Update: 2022-11-30