|Table of Contents|

Analysis of differential genes and biological functions of radiosensitivity in prostate cancer:Based on GEO database

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 06
Page:
1056-1059
Research Field:
Publishing date:

Info

Title:
Analysis of differential genes and biological functions of radiosensitivity in prostate cancer:Based on GEO database
Author(s):
HUANG Wenlin; XU Yong; QU Genyi; DUAN Guangjun; ZHANG Yulong; LIU Ziwei
The Second Department of Urology,Zhuzhou Hospital Affiliated to Xiangya School of Medicine,Central South University,Hunan Zhuzhou 412007,China.
Keywords:
prostate cancer; radiosensitivity; bioinformatics analysis
PACS:
R737.25
DOI:
10.3969/j.issn.1672-4992.2022.06.021
Abstract:
Objective:To explore the potential relationship between differential gene expression,biological function enrichment and disease prognosis affecting the sensitivity of prostate cancer radiotherapy using bioinformatics.Methods:Retrieve and obtain data on differential gene expression of prostate cancer radiosensitivity in the GEO database (GSM3954350,GSM3954351,GSM3954352).GER2 tool was used to screen and analyze the differential genes.Enrichr database performed enrichment analysis of GO and KEGG.Cytoscape software built protein-protein interaction (PPI) networks and analyzed key genes.Results:A total of 7 041 differentially expressed genes were screened,including 3 842 high expression genes and 3 199 low expression genes.The top 20 differentially expressed genes were selected for further analysis.Their biological functions were mainly enriched in the following aspects:Nuclease activity regulation,enzyme-linked receptor protein signaling pathway,nucleotide excision repair,DNA gap filling.Cytological components were mainly located outside the cell.Molecular functions were enriched in structural molecular activity,receptor binding,serine-type peptidase activity,etc.The analysis of KEGG signaling pathway showed that the differential genes were mainly enriched in the mismatch repair pathway,non-homologous terminal binding pathway and so on.Conclusion:Through the analysis of the differential genes related to the radiosensitivity of prostate cancer,the key differential genes found in this study can help to understand the potential molecular mechanism of prostate cancer radiotherapy resistance,and can provide a theoretical basis for further improving the effectiveness of radiation therapy of prostate cancer.

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Memo

Memo:
湖南省自然科学基金（编号：2020JJ8054）
Last Update: 1900-01-01