|Table of Contents|

Advances in the study of regulatory targets for high-risk human papillomavirus oncogenes E6 and E7

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 04
Page:
748-752
Research Field:
Publishing date:

Info

Title:
Advances in the study of regulatory targets for high-risk human papillomavirus oncogenes E6 and E7
Author(s):
LIU MiaoSUN Zhengrong
Biobank of Shengjing Hospital Affiliated to China Medical University,Liaoning Shenyang 110000,China.
Keywords:
high-risk human papillomavirusE6E7cellular target
PACS:
R730
DOI:
10.3969/j.issn.1672-4992.2022.04.042
Abstract:
Infection of high-risk human papillomavirus (HPV) is closely related to a variety of human cancers,the most prominent of which is cervical cancer.The two most important viral oncogenes for high-risk HPV are E6 and E7,and the integration of the viral genome into the host genome is one of the manners in which the viral oncogenes E6 and E7 achieve persistent expression.HPV exerts its tumorigenicity in cells.The most well-studied cellular targets for viral oncogenes E6 and E7 are p53 and pRb,respectively.However,recent studies have shown that the ability of these two viral proteins to target more cellular factors,including proteins that regulate epigenetic markers and splicing changes in cells.HPV oncogenes E6 and E7 have the ability to exert a global change in cells through these interactions,which eventually culminates to uncontrolled proliferation and carcinogenesis.

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辽宁省重点研发计划(编号:2018225009);辽宁省高等学校基本科研项目(编号:LFWK201710)
Last Update: 1900-01-01