[1] JEFFRIES KA,KRUPENKO NI.Ceramide signaling and p53 pathways［J］.Adv Cancer Res,2018,140:191-215.
[2] INSAUSTI-URKIA N,SOLSONA-VILARRASA E,GARCIA-RUIZ C,et al.Sphingomyelinases and liver diseases［J］.Biomolecules,2020,10(11):1497.
[3] PARSIEGLA G,NOGUERE C,SANTELL L,et al.The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily［J］.Biochemistry,2012,51(51):10250-10258.
[4] HOFMANN K,TOMIUK S,WOLFF G,et al.Cloning and characterization of the mammalian brain-specific,Mg2+-dependent neutral sphingomyelinase［J］.Proc Natl Acad Sci USA,2000,97(11):5895-5900.
[5] WU BX,CLARKE CJ,MATMATI N,et al.Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference［J］.J Biol Chem,2011,286(25):22362-22371.
[6] AIROLA MV,SHANBHOGUE P,SHAMSEDDINE AA,et al.Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation［J］.Proc Natl Acad Sci USA,2017,114(28):E5549-E5558.
[7] NGANGA R,OLEINIK N,OGRETMEN B.Mechanisms of ceramide-dependent cancer cell death［J］.Adv Cancer Res,2018,140:1-25.
[8] OGRETMEN B.Sphingolipid metabolism in cancer signalling and therapy［J］.Nat Rev Cancer,2018,18(1):33-50.
[9] HERNANDEZ-TIEDRA S,FABRIAS G,DAVILA D,et al.Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization［J］.Autophagy,2016,12(11):2213-2229.
[10] KITATANI K,USUI T,SRIRAMANSK,et al.Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer:potential of ceramide as a metastasis-suppressor lipid［J］.Oncogene,2016,35(21):2801-2812.
[11] WANG P,YUAN Y,LIN W,et al.Roles of sphingosine-1-phosphate signaling in cancer［J］.Cancer Cell Int,2019,19:295.
[12] UEDA N.Ceramide-induced apoptosis in renal tubular cells:a role of mitochondria and sphingosine-1-phoshate［J］.Int J Mol Sci,2015,16(3):5076-5124.
[13] ZHONG L,KONG JN,DINKINS MB,et al.Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice［J］.J Lipid Res,2018,59(5):795-804.
[14] WANG J,LI J,GU J,et al.Abnormal methylation status of FBXW10 and SMPD3,and associations with clinical characteristics in clear cell renal cell carcinoma［J］.Oncol Lett,2015,10(5):3073-3080.
[15] KIM WJ,OKIMOTO RA,PURTON LE,et al.Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias［J］.Blood,2008,111(9):4716-4722.
[16] MIRANDA I.Overexpression of nSMase2 in 4T1 and E0771 breast cancer cells confers varying oncogenic properties［D］.Stony Brook:State University of New York,2019:1-43.
[17] LIU M,ZHU K,QIAN X,et al.Identification of miRNA/mRNA-negative regulation pairs in nasopharyngeal carcinoma［J］.Med Sci Monit,2016,22:2215-2234.
[18] SHAKOR AB,ATIA M,ISMAIL IA,et al.Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation［J］.Biochim Biophys Acta,2014,1841(12):1672-1682.
[19] CHIPUK JE,MCSTAY GP,BHARTI A,et al.Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis［J］.Cell,2012,148(5):988-1000.
[20] SHAMSEDDINE AA,CLARKE CJ,CARROLL B,et al.p53-dependent upregulation of neutral sphingomyelinase-2:role in doxorubicin-induced growth arrest［J］.Cell Death Dis,2015,6(10):e1947.
[21] LUBERTO C,HASSLER DF,SIGNORELLI P,et al.Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase［J］.J Biol Chem,2002,277(43):41128-41139.
[22] SHAKOR AB,ATIA M,ISMAIL IA,et al.Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation［J］.Biochim Biophys Acta,2014,1841(12):1672-1682.
[23] MONDAL S,MANDAL C,SANGWAN R,et al.Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase［J］.Mol Cancer,2010,9(1):1-17.
[24] MARCHESINI N,OSTA W,BIELAWSKI J,et al.Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells［J］.J Biol Chem,2004,279(24):25101-25111.
[25] BESIM OGRETMEN,JACQUELINE M KRAVEKA,DEBORAH SCHADY,et al.Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line［J］.J Biol Chem,2001,276(35):32506-32514.
[26] CODINI M,CONTE C,CATALDI S,et al.Nuclear lipid microdomains regulate daunorubicin resistance in hepatoma cells［J］.Int J Mol Sci,2018,19(11):3424.
[27] CLARKE CJ,SHAMSEDDINE AA,JACOB JJ,et al.ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation［J］.J Lipid Res,2016,57(5):868-881.
[28] AHEGET H,MAZINI L,MARTIN F,et al.Exosomes:their role in pathogenesis,diagnosis and treatment of diseases［J］.Cancers (Basel),2020,13(1):84.
[29] KOSAKA N,IGUCHI H,HAGIWARA K,et al.Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis［J］.J Biol Chem,2013,288(15):10849-10859.
[30] SINGH R,POCHAMPALLY R,WATABE K,et al.Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer［J］.Molecular Cancer,2014,13(1):1-11.
[31] KONG JN,HE Q,WANG G,et al.Guggulsterone and bexarotene induce secretion of exosome-associated breast cancer resistance protein and reduce doxorubicin resistance in MDA-MB-231 cells［J］.Int J Cancer,2015,137(7):1610-1620.
[32] BASTOS N,RUIVO CF,DA SILVA S,et al.Exosomes in cancer:Use them or target them［J］.Semin Cell Dev Biol,2018,78:13-21.
[33] KUBOTA S,CHIBA M,WATANBE M,et al.Secretion of small/microRNAs including miR-638 into extracellular spaces by sphingomyelin phosphodiesterase 3［J］.Oncol Rep,2015,33(1):67-73.
[34] LIAO J,LIU R,SHI YJ,et al.Exosome-shuttling microRNA-21 promotes cell migration and invasion-targeting PDCD4 in esophageal cancer［J］.Int J Oncol,2016,48(6):2567-2579.
[35] AL-RASHED F,AHMAD Z,THOMAS R,et al.Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α［J］.Sci Rep,2020,10(1):16802.
[36] KARAKASHIAN AA,GILTIAV NV,SMITH GM,et al.Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation［J］.FASEB J,2004,18(9):968-970.