|Table of Contents|

Expression of miR-512-3p and Livin in bladder cancer tissues and their relationship with the effect of anthracycline containing neoadjuvant chemotherapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 04
Page:
680-684
Research Field:
Publishing date:

Info

Title:
Expression of miR-512-3p and Livin in bladder cancer tissues and their relationship with the effect of anthracycline containing neoadjuvant chemotherapy
Author(s):
LIANG Junfeng; XING Jiawei; LIU Xu; JIA Pengchong
Department of Urology,Henan Provincial Hospital,Henan Zhengzhou 451161,China.
Keywords:
bladder cancer; microRNA-512-3p; Livin; anthracycline containing neoadjuvant chemotherapy effect
PACS:
R737.14
DOI:
10.3969/j.issn.1672-4992.2022.04.024
Abstract:
Objective:To detect the expression levels of microRNA-512-3p(miR-512-3p) and Livinin cancer tissues of patients with bladder cancer,and to explore the relationship between the expression levels of miR-512-3p and Livin and the effect of neoadjuvant chemotherapy with anthracyclines.Methods:From June 2011 to January 2015,52 patients with bladder cancer diagnosed by pathology in urology department of our hospital were selected as the research objects.All patients were treated with anthracycline containing neoadjuvant chemotherapy before operation.The relationship between the expression levels of miR-512-3p,Livin and the effect of anthracycline containing neoadjuvant chemotherapy and the 5-year survival rate after treatment in patients with bladder cancerwas observed.Results:The expression level of miR-512-3p in bladder cancer was 0.71±0.22,and the expression level of miR-512-3p in bladder cancer was 1.46±0.35.The expression level of miR-512-3p in phase G3 patients was significantly lower than that in phase G2 and G1 patients(P＜0.05),and the expression level of Livin was significantly higher than that in phase G2 and G1 patients(P＜0.05).The expression level of miR-512-3p in T2-T4 patients was significantly lower than that in T0-T1 patients(P＜0.05),and the expression level of Livin was significantly higher than that in T0-T1 patients(P＜0.05).The expression level of miR-512-3p in patients with distant metastasis was significantly lower than that in patients without distant metastasis(P＜0.05),and the expression level of Livin was significantly higher than that in patients without distant metastasis(P＜0.05).The good rate of miR-512-3p high expression group was significantly higher than that of miR-512-3p low expression group(P＜0.05).The good rate of Livin high expression group was significantly lower than that of Livin low expression group(P＜0.05).The good rate of clinical treatment in patients with high expression of miR-512-3p and low expression of Livin was significantly higher than other patients(P＜0.05).Survival curve analysis showed that the 5-year overall survival rate of patients in the high expression group of miR-512-3p was higher than that in the low expression group of miR-512-3p(P＜0.05),and the overall survival rate of patients in the low expression group of Livin was higher than that in the high expression group of Livin(P＜0.05),and the 5-year overall survival rate after treatment in the combined group of miR-512-3p high expression and low Livin expression was significantly higher than that of other patient groups(P＜0.05).Conclusion:The expression levels of miR-512-3p and Livin in bladder cancer are related to pathological grade and stage,distant metastasis,chemotherapy efficacy and survival prognosis,suggesting miR-512-3p,Livin may be used as important indicators to predict the effect of neoadjuvant chemotherapy containing anthracyclines in patients with bladder cancer.

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Memo

Memo:
河南省医学科技攻关计划联合共建项目（编号：LHGJ20190853,LHGJ20191317）
Last Update: 1900-01-01