|Table of Contents|

The value of circulating tumor cell count and circulating tumor endothelial cell count in monitoring postoperative recurrence and metastasis of localized renal carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 04
Page:
663-669
Research Field:
Publishing date:

Info

Title:
The value of circulating tumor cell count and circulating tumor endothelial cell count in monitoring postoperative recurrence and metastasis of localized renal carcinoma
Author(s):
LIU Xin; WANG Zhiyong; CHI Qiang; MIAO Yuesong; LIU Jie
Department of Urology,Affiliated Hospital of Chengde Medical College,Hebei Chengde 067000，China.
Keywords:
renal carcinoma; circulating tumor cells; circulating tumor-derived endothelial cell
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2022.04.021
Abstract:
Objective:To investigate the role of the number of circulating tumor cells and circulating tumor endothelial cells in predicting the recurrence and metastasis of localized renal carcinoma after radical or partial nephrectomy.Methods:7.5 mL peripheral blood was collected from 52 patients with localized renal carcinoma before and 3 months after operation,and from 20 healthy patients.The number of circulating tumor cells and circulating endothelial cells after operation was higher than that before operation.Patients in the two groups were followed up,the end point was tumor recurrence and metastasis,and the longest follow-up time was 21 months.Results:The recurrence and metastasis rate in the CTC positive group was 61.9%(13/21),significantly higher than that in the negative group 19.4%(6/31),with statistically significant difference(P=0.003).The recurrence and metastasis rate in the CTEC positive group was 57.1%(12/21),the recurrence and metastasis rate in the negative group was 22.6%(7/31),with statistically significant difference(P=0.012),and the recurrence and metastasis rate in the double-positive group was 75.0%(12/16).Conclusion:Patients with renal carcinoma whose circulating tumor cell count was higher 3 months after surgery than that before surgery were prone to recurrence and metastasis.If the circulating tumor endothelial cell count was also higher than that before surgery,the recurrence and metastasis rate of patients might be higher.The changes in the number of circulating tumor cells and circulating tumor endothelial cells can be used as better monitoring indexes after renal carcinoma operation.

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