|Table of Contents|

Analysis of early diagnosis value of serum TSGF and VEGF-C in lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

2022 04
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Analysis of early diagnosis value of serum TSGF and VEGF-C in lung cancer
WU Jiang1LIU Hongping1ZHAO Mingcai1WANG Fen1DENG Rong1WU Hongwei2
1.Department of Laboratory Medicine,Suining Central Hospital,Sichuan Suining 629000,China;2.Department of Hematology,the First Affiliated Hospital of Chengdu Medical College,Sichuan Chengdu 610500,China.
lung cancerearly diagnosistumor-specific growth factorvascular endothelial growth factor C
Objective:To analyze the value of serum tumor-specific growth factor(TSGF) and vascular endothelial growth factor C(VEGF-C) in the early diagnosis of lung cancer.Methods:The patients with lung cancer diagnosed by pathology and CT diagnosed(80 cases) and patients with benign lung disease(50 cases) in our hospital from February 2018 to December 2019 were selected as the lung cancer group and benign lung disease group.Enzyme-linked immunosorbent assay was used to detect serum TSGF and VEGF-C levels in two groups of patients before treatment.The differences of serum TSGF,VEGF-C and other factors that may cause lung cancer between the two groups were compared,and the risk factors of lung cancer were determined by logistic regression analysis.Draw the receiver characteristic working curve(ROC),and calculate the area under the curve(AUC),and analyze the serum TSGF,VEGF-C levels for the early diagnosis of lung cancer.Kappa consistency was used to test the consistency between the gold standard of combined diagnosis of serum TSGF and VEGF-C and pathological diagnosis.Results:The proportion of patients with poor emotion regulation,smoking,family tumor history,respiratory disease history and the levels of serum TSGF and VEGF-C in lung cancer group were higher than those in benign lung disease group(P<0.05),and multi-factor Logistic regression analysis showed that the above factors were all independent risk factors of lung cancer(P<0.05).ROC results showed that the best cut-off points for TSGF and VEGF-C in the diagnosis of early lung cancer were 604.50 U/mL and 28.70 ng/L,and AUC was 0.794 and 0.732,respectively.With TSGF>604.50 U/mL and VEGF-C>28.70 ng/L as the positive diagnostic criteria for early lung cancer,tandem diagnosis was performed.After Kappa consistency test,TSGF combined with VEGF-C had a high consistency with the gold standard for pathological examination(Kappa=0.754,P<0.05).Conclusion:TSGF and VEGF-C are abnormally highly expressed in the serum of lung cancer patients.The serum level of TSGF and the serum level of VEGF-C are of high value for the early diagnosis of lung cancer,and the combined application of the two has a higher diagnostic efficiency.


[1]FIELD JK,DUFFY SW,BALDWIN DR,et al.The UK Lung Cancer Screening Trial:a pilot randomised controlled trial of low-dose computed tomography screening for the early detection of lung cancer [J].Health Technol Assess,2016,20(40):1-146.
[2]MOK TSK,WU YL,KUDABA I,et al.Pembrolizumab versus chemotherapy for previously untreated,PD-L1-expressing,locally advanced or metastatic non-small-cell lung cancer(KEYNOTE-042):a randomised,open-label,controlled,phase 3 trial [J].Lancet,2019,393(10183):1819-1830.
[3]FORDE PM,CHAFT JE,SMITH KN,et al.Neoadjuvant PD-1 blockade in resectable lung cancer[J].N Engl J Med,2018,378(21):1976-1986.
[4]邓岳红,钱沁佳.血清miR-375、TSGF、SCC联合检测对宫颈癌的诊断价值[J].山东医药,2018,58(38):66-68. DENG YH,QIAN QJ.The diagnostic value of combined detection of serum miR-375,TSGF,and SCC for cervical cancer[J].Shandong Medical Journal,2018,58(38):66-68.
[5]YAN T,ZHANG GH,WANG BN,et al.Effects of propofol/remifentanil-based total intravenous anesthesia versus sevoflurane-based inhalational anesthesia on the release of VEGF-C and TGF-β and prognosis after breast cancer surgery:a prospective,randomized and controlled study [J].BMC Anesthesiol,2018,18(1):131.
[6]赵鑫,张冰人,张鹏,等.斯坦福情绪调节量表在我国中学生中的信、效度检验[J].中国临床心理学杂志,2015,23(1):22-25. ZHAO X,ZHANG BR,ZHANG P,et al.Reliability and validity of emotion regulation questionnaire in middle school students [J].Chinese Journal of Clinical Psychology,2015,23(1):22-25.
[7]WILLE MM,DIRKSEN A,ASHRAF H,et al.Results of the randomized danish lung cancer screening trial with focus on high-risk profiling [J].Am J Respir Crit Care Med,2016,193(5):542-551.
[8]JAMAL-HANJANI M,WILSON GA,MCGRANAHAN N,et al.Tracking the evolution of non-small-cell lung cancer [J].N Engl J Med,2017,376(22):2109-2121.
[9]方芳,乔旭柏,杨丽,等.用2015 WHO肺肿瘤分类诊断肺穿刺活检标本及相关肿瘤驱动基因的突变检测[J].中华病理学杂志,2019,48(4):270-275. FANG F,QIAO XB,YANG L,et al.Diagnosis of lung biopsy employing the 2015 WHO criteria and detection of related oncogenic driver mutations [J].Chinese Journal of Pathology,2019,48(4):270-275.
[10]PAUL R,APORNPONG T,PRASITSUEBSAI W,et al.Cognition,emotional health,and immunological markers in children with long-term nonprogressive HIV [J].J Acquir Immune Defic Syndr,2018,77(4):417-426.
[11]BENOWITZ NL,GAN Q,GONIEWICZ ML,et al.Different profiles of carcinogen exposure in Chinese compared with US cigarette smokers [J].Tob Control,2015,24(4):258-263.
[12]GOLD DR,LITONJUA AA,CAREY VJ,et al.Lung VITAL:Rationale,design,and baseline characteristics of an ancillary study evaluating the effects of vitamin D and/or marine omega-3 fatty acid supplements on acute exacerbations of chronic respiratory disease,asthma control,pneumonia and lung function in adults [J].Contemp Clin Trials,2016,47:185-195.
[13]TAMMEMAGI MC,SCHMIDT H,MARTEL S,et al.Participant selection for lung cancer screening by risk modelling(the Pan-Canadian Early Detection of Lung Cancer [PanCan] study):a single-arm,prospective study [J].Lancet Oncol,2017,18(11):1523-1531.
[14]姚红,高峰,胡芳.恶性肿瘤患者肿瘤特异性生长因子水平及其临床意义[J].现代仪器与医疗,2018,24(3):103-105. YAO H,GAO F,HU F.Tumor specific growth factor levels in patients with malignant tumor and its clinical significance [J].Modern Instruments & Mediccal Treatment,2018,24(3):103-105.
[15]周小军,周凤姣.鼻咽癌及其高危者血清肿瘤特异性生长因子表达水平研究[J].中国中西医结合耳鼻咽喉科杂志,2018,26(4):250-252. ZHOU XJ,ZHOU FJ.Serum tumor-specific growth factor levels in nasopharyngeal carcinoma and its high-risk patients [J].Chinese Journal of Otorhinolaryngology in Integrative Medicine,2018,26(4):250-252.
[16]李珣,张祥林.肝动脉化疗栓塞联合恩替卡韦对原发性肝癌治疗效果及对患者血清中恶性肿瘤特异性生长因子的影响[J].陕西医学杂志,2019,48(7):873-875. LI X,ZHANG XL.Efficacy observation and TSGF change in primary hepatocellular carcinoma by TACE and entecavir [J].Shaanxi Medical Journal,2019,48(7):873-875.
[17]DAVYDOVA N,HARRIS NC,ROUFAIL S,et al.Differential receptor binding and regulatory mechanisms for the lymphangiogenic growth factors vascular endothelial growth factor(VEGF)-C and-D [J].J Biol Chem,2016,291(53):27265-27278.
[18]齐发梅,魏莲花,周爱花,等.肝炎病毒载量与恶性肿瘤特异性生长因子相关性分析[J].中国卫生检验杂志,2019,29(4):430-431,437. QI FM,WEI LH,ZHOU AH,et al.Relationship between hepatitis virus load and TSGF [J].Chinese Journal of Health Laboratory Technology,2019,29(4):430-431,437.


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