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Comparison of efficacy and analysis of factors affecting prognosis of malignant glioma treated with radiotherapy and concurrent chemoradiotherapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

2022 04
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Comparison of efficacy and analysis of factors affecting prognosis of malignant glioma treated with radiotherapy and concurrent chemoradiotherapy
TIAN BiSUN XudongMA JianLI PengpengSHI ChangliDING GuangchengQIN DehuaBU Yajing
Gamma Knife Center,the Fifth Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450000,China.
three-dimensional conformal radiation therapytemozolomidemalignant gliomaprognosisinfluencing factors
Objective:To investigate the prognostic factors of three-dimensional conformal radiation therapy (3DCRT) combined with temozolomide (TMZ) in the treatment of malignant glioma.Methods:The clinical data of 120 cases of malignant glioma patients in our hospital from January 2012 to June 2015 were retrospectively analysed.All patients underwent intracranial tumor resection,including 3DCRT in 56 patients (radiotherapy group),postoperative 3DCRT combined with TMZ oral treatment in 64 patients (chemoradiotherapy group).The efficacy of the two groups of treatment were compared,and survival analysis was performed using the Kaplan-Meier method,and univariate analysis and Cox regression multivariate analysis were used to investigate the independent influencing factors affecting the prognosis of patients with malignant glioma.Results:The 1-year survival rate and 2-year survival rate of the patients in the chemoradiotherapy group were 88.33% and 79.68%,respectively,which were significantly higher than that of the radiotherapy group (78.57%,55.36%,P<0.05),and the median survival time of the chemoradiotherapy group was significantly longer than that of the radiotherapy group (28.4 months vs 21.3 months).The median progression-free survival (mPFS) of the chemoradiotherapy group was significantly longer than that of the radiotherapy group (20.1 months vs 16.5 months).The 1-year survival rate and 2-year survival rate of grade Ⅲ patients were 93.33% and 82.54%,respectively,which were significantly higher than those of grade Ⅳ patients (75.00%,54.29%,P<0.05),and the median survival time of grade Ⅲ patients was significantly longer than that of grade Ⅳ (54.5 months vs 17.8 months).And the mPFS of grade Ⅲ patients was significantly longer than that of grade Ⅳ (32.4 months vs 14.6 months) (P<0.05).Univariate analysis showed that age,pathological grade,preoperative KPS score,peritumoral edema,degree of surgical resection,tumor site,and number of lesions were significant factors affecting the median survival time of patients with malignant glioma(P<0.05).Multivariate analysis results indicated that age,pathological grade,and preoperative KPS score were independent risk factors for postoperative survival in patients with malignant glioma.Conclusion:Radiotherapy combined with TMZ chemotherapy can significantly prolong the median survival of patients with malignant glioma.The prognosis of patients with malignant glioma is significantly correlated with age,pathological grade and preoperative KPS score.


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