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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2022 03

Page:

436-442

Research Field:

Publishing date:

Info

Title:

Identification of an acquired EGFR-TKI resistance-related gene signature and its value of prognosis prediction in lung adenocarcinoma

Author(s):

ZHOU Lingqiao¹; TANG Xiong²; MO Mengchun²; QIU Shaomian²

1.The People's Hospital of Bishan District,Chongqing Bishan 402760,China;2.Guangdong Provincial People's Hospital,Guangdong Guangzhou 510080,China.

Keywords:

LUAD; acquired EGFR-TKI resistance; prognosis; gene signature

PACS:

R734.2

DOI:

10.3969/j.issn.1672-4992.2022.03.013

Abstract:

Objective:To search for an effective acquired epidermal growth factor receptor-tyosine kinase inhibitor(EGFR-TKI) resistance-related gene signature,and use it to predict prognosis of lung adenocarcinoma.Methods:Univariate and multivariable Cox proportional hazards regression were applied to identify an acquired EGFR-TKI resistance-related gene signature,and gene signature-based prognostic risk score model was constructed.The function of gene signature was annotated by gene ontology(GO).Results:Acquired EGFR-TKI resistance genes(MYO1D,PCDH7,TNFSF15,COL4A6,BEX2,WFDC21P,CADPS2) were screened out as a gene signature of prognosis for lung adenocarcinoma(LUAD),and gene signature-based prognostic model was constructed.For the constructed prognostic risk score model,according to the analysis of Kaplan-Meier and ROC,5-year survival rate of high-risk patients(37.8%) was lower than that of low-risk patients(71.5%) in training dataset(P£¼0.001),and the area under the curve(AUC) was 0.743,5-year survival rate of high-risk patients(25.6%) was lower than that of low-risk patients(49.8%) in validation dataset(P£¼0.001),and the AUC was 0.719.The results showed that the risk score model had a powerful predictive ability.At the same time,Cox proportional hazards regression analysis of risk score and other clinical information verified that risk score was an independent prognostic factor,and it further showed that the selected gene signature was an independent prognostic factor.GO functional analysis revealed that the selected gene signature may regulate the prognosis of LUAD from actin,extracellular matrix,apoptosis and the likes.Conclusion:The selected acquired EGFR-TKI resistance gene signature is an independent prognostic factor and might be a therapeutic target for LUAD.

References:

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Last Update: 2021-12-31