|Table of Contents|

The expression of GOLM1 in lung adenocarcinoma tissues and its effect on the cell proliferation,migration and invasion of A549 cells

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 03
Page:
412-415
Research Field:
Publishing date:

Info

Title:
The expression of GOLM1 in lung adenocarcinoma tissues and its effect on the cell proliferation,migration and invasion of A549 cells
Author(s):
JIA Chunli1; ZHANG Hua1; LU Pengfei1; YANG Ying1; LI Li2; HU Jun2; ZHU Haipeng2
1.Cancer Center,the First Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830000,China;2.Hematology Oncology Department,Karamay Central Hospital,Xinjiang Karamay 834000,China.
Keywords:
GOLM1; lung adenocarcinoma; cell proliferation; cell migration; cell invasion
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2022.03.009
Abstract:
Objective:To investigate the expression of Golgi phosphoprotein 2(GOLM1) in lung adenocarcinoma tissues and the effect on proliferation,migration and invasion of A549 cells.Methods:The expression of GOLM1 mRNA in lung adenocarcinoma tissues and its correlation with prognosis were analyzed from GEPIA database.Lentiviral siRNA technology was used to down regulate the expression of GOLM1 in human lung adenocarcinoma A549 cells.Real-time PCR was used to verify the silencing effect.CCK-8,cell scratch test and Transwell test were used to detect the cell proliferation,migration and invasion.Results:GOLM1 mRNA was highly expressed in lung adenocarcinoma(P＜0.05).The overall survival time of patients with high GOLM1 mRNA expression was significantly lower than that of patients with low GOLM1 expression(P＜0.05).The proliferation,migration and invasion of A549 cells were significantly decreased after GOLM1 knockdown(P＜0.05).Conclusion:GOLM1 is highly expressed in lung adenocarcinoma,silencing its expression can inhibit cell proliferation,migration and invasion of lung adenocarcinoma cells.It can be used as a potential prognostic marker and therapeutic target for lung adenocarcinoma.

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Memo

Memo:
新疆维吾尔自治区自然科学基金资助项目（编号：2019D01A07）
Last Update: 2021-12-31