|Table of Contents|

Detection of serum exosomal integrin β4 and its correlation between clinicopathological features and lung metastasis in osteosarcoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 01
Page:
112-116
Research Field:
Publishing date:

Info

Title:
Detection of serum exosomal integrin β4 and its correlation between clinicopathological features and lung metastasis in osteosarcoma
Author(s):
WANG Qianrong; LIU Wenchao; ZHANG Hongmei
Department of Clinical Oncology，Xijing Hospital，Air Force Medical University，Shaanxi Xi'an 710032,China.
Keywords:
osteosarcoma; lung metastasis; exosome integrin β4
PACS:
R738.1
DOI:
10.3969/j.issn.1672-4992.2022.01.024
Abstract:
Objective:To detect the level of serum exosome integrin β4 in patients with osteosarcoma and to analyze the correlation between it and clinicopathological features,so as to provide a theoretical basis for the prediction of lung metastasis of osteosarcoma.Methods:This study included osteosarcoma who the peripheral blood of the patients was collected,and the patients were divided into the pre-operative group,the postoperative non-pulmonary metastasis group and the post-operative lung metastasis group.The morphology and size of the external urinary tract of the three groups were identified by flow cytometry and Western-Blot.Finally,the relationship between the clinical characteristics of the patient and the integrin β4 in the serum was analyzed.Results:The results showed that the pulmonary metastasis group after operation> the preoperative group＞ the no pulmonary metastasis group after operation.It is suggested that exsome integrin β4 is related to pulmonary metastasis of osteosarcoma.The analysis of patient data showed that exsome integrin β4 was correlated with the stage of osteosarcoma patients(P=0.01).It was correlated with lung metastasis(P=0.001 8),and size of lung metastasis(P=0.007 6).There was no significant correlation of patient's gender,tumor location,primary tumor size,operation or not,preoperative neoadjuvant chemotherapy or not and the efficacy of neoadjuvant chemotherapy.Conclusion:Exsome integin β4 plays a guiding role in lung metastasis of osteosarcoma.It is expected to be a molecular marker for lung metastasis of osteosarcoma.

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Memo

Memo:
National Natural Science Foundation of China(No.81572699）；国家自然科学基金（编号：81572699）；空军军医大学第一附属医院2019年度学科助推项目（编号：XJZT18MDT18）
Last Update: 2021-12-02