|Table of Contents|

Clinicopathological characteristics of myxoid adrenocortical adenoma with a pseudoglandular pattern and literature review

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 01
Page:
84-88
Research Field:
Publishing date:

Info

Title:
Clinicopathological characteristics of myxoid adrenocortical adenoma with a pseudoglandular pattern and literature review
Author(s):
XIE Min1; SUN Ran1; XU Lei2; XU Zengxiang3
1.Department of Pathology；2.Department of Urology,Wuhu No.2 People's Hospital,Anhui Wuhu 241001,China；3.Department of Pathology,Wannan Medical College,Anhui Wuhu 241001,China.
Keywords:
myxoid adrenocortical adenoma; pseudoglandular; capsule invasion; pathology
PACS:
R736.6
DOI:
10.3969/j.issn.1672-4992.2022.01.018
Abstract:
Objective:To study the clinicopathological characteristics and the behavior of pseudoglandular myxoid adrenocortical adenoma(MACA).Methods:A case of MACA with pseudoadenoid structure was reviewed.The expression of Vimentin,Melan-A,CD56,NSE in tumor tissue was detected by immunohistochemistry.Meanwhile follow up and literature review were performed.Results:A 49-year-old male patient presented with a right adrenal gland tumor.Grossly,the mass was mostly solid,roundish and with clear boundaries,cutting indicated greyish white to local translucence.Histologically,tumor was demarcated by a thin fibrous capsule,focal involvement of fibrous capsule and atrophic adrenal gland tissue were found.The tumor was arranged in pseudoglandular pattern and cords,microcystic,glomerular structure with a rich background of mucus.The tumor cells were small to medium,eosinophilic,or transparent,with round to oval nucleus,occasionally visible nucleoli,and rare mitotic figure.The tumor showed no evidence of necrosis or vascular invasion.Immunohistochemical staining showed positive expression of Vimentin，Melan-A，CD56，NSE,and Ki-67 index was less than 5%.Histochemical staining for Alcian-blue highlighted the abundant eosinophilic myxoid material.Conclusion:MACA is a rare benign tumor of adrenal neoplasm frequently accompanied by a pseudoglandular pattern,but capsule invasion was scarce.Clinicopathologic significance of this growth pattern needs more cases to be further observed.The clinical diagnosis of the tumor should be based on the clinical features,imaging and pathological features,while excluding metastatic adenocarcinoma and other retroperitoneal tumors with mucinous degeneration.The patients should be followed-up after complete excision．

References:

[1] BROWN FM,GAFFEY TA,WOLD LE,et al.Myxoid neoplasms of the adrenal cortex:a rare histologic variant［J］.Am J Surg Pathol,2000,24(3):396-401.
[2] 赵丽娜,袁静萍,曾智,等.2例伴有假腺样结构的黏液样肾上腺皮质腺瘤临床病理观察［J］.临床与病理学杂志,2019,39(11):2554-2559. ZHAO Lina,YUAN Jingping,ZENG Zhi,et al.Two cases of mucinous adrenocortical adenoma with pseudoadenoid structure:a clinicopathologic study of 2 cases ［J］.Journal of Clinical Pathology,2019,39(11):2554-2559.
[3] WU HM,LIU C,LIU XH,et al.Clinicopathologic features of myxoid adrenocortical adenomas［J］.Chinese journal of Pathology,2018,47(7):527-530.
[4] 王彩霞,崔林.伴假腺样结构的黏液性肾上腺皮质腺瘤［J］.医药前沿,2018,8(36):253-254. WANG Caixiang,CUI Lin.Mucinous adrenocortical adenoma with pseudoadenoid structure ［J］.Medical Frontier,2018,8(36):253-254.
[5] 宋楷，许晓明，魏树梅.上皮标记阳性的黏液性肾上腺皮质腺瘤1例［J］.诊断病理学杂志,2017,24(8):633-634. SONG Kai,XU Xiaoming,WEI Shumei.A case of mucinous adrenocortical adenoma with positive epithelial markers ［J］.Journal of Diagnostic Pathology,2017,24(8):633-634.
[6] 戴桂红,魏雪,吴楠,等.伴假腺样结构的黏液型肾上腺皮质腺瘤6例临床病理特征分析［J］.临床与实验病理学杂志,2016,32(4):388-391. DAI Guihong,WEI Xue,WU Nan,et al.A clinicopathological analysis of 6 cases of mucinous adrenocortical adenoma with pseudoadenoid structure ［J］.Journal of Clinical and Experimental Pathology,2016,32(4):388-391.
[7] CHATTERJEE G,DASGUPTA S,BHATTACHARYA K,et al.Myxoid adrenal cortical adenoma in an infant:An unusual morphology［J］.J Cancer Res Ther,2015,11(4):1040.
[8] KIM TU,KIM S,LEE JW,et al.Myxoid adrenocortical adenoma:magnetic resonance imaging and pathology correlation［J］.Korean J Radiol,2014,15(2):245-249.
[9] 王彩霞,文娟娟,徐艳,等.伴假腺样结构的黏液性肾上腺皮质腺瘤1例［J］.诊断病理学杂志,2014,21(1):61-62. WANG Caixiang,WEN Juanjuan,XU Yan,et al.A case of mucinous adrenocortical adenoma with pseudoadenoid structure ［J］.Journal of Diagnostic Pathology,2014,21(1):61-62.
[10] 肖芹,顾学文,朱长仁,等.黏液性肾上腺皮质腺瘤的临床病理分析［J］.中华临床医师杂志(电子版),2014,8(11):2006-2009. XIAO Qin,GU Xuewen,ZHU Changren,et al.Clinicopathological analysis of mucinous adrenocortical adenoma ［J］.Chinese Journal of Clinicians(Electronic Edition),2014,8(11):2006-2009.
[11] 祝宇,吴瑜璇,张舯宇,等.黏液样肾上腺皮质腺瘤一例［J］.中华外科杂志,2008,46(3):239. ZHU Yu,WU Yuxuan,ZHANG Zhongyu,et al.A case of myxoid adrenocortical adenoma ［J］.Chinese Journal of Surgery,2008,46(3):239.
[12] RAPARIA K,AYALA AG,SIENKO A,et al.Myxoid adrenal cortical neoplasms［J］.Ann Diagn Pathol,2008,12(5):344-348.
[13] DUNDR P，NOVAK K.Pseudoglandular myxoid adenoma of the adrenal gland［J］.Pathol Res Pract,2003,199(7):493-496．
[14] BOLLITO ER,PAPOTTI M,PORPIGLIA F,et al.Myxoid adrenocortical adenoma with a pseudoglandular pattern［J］.Virchows Arch,2004,445(4):414-418．
[15] DE PADUA M,RAJAGOPAL V.Myxoid adrenal adenoma with focal pseudoglandular patern［J］.Indian J Med Sci,2008,62(5):199-203.
[16] 杜强,冯向东,李燕东.伴假腺样结构的黏液样肾上腺皮质腺瘤1例［J］.诊断病理学杂志,2005,12(6):479. DU Qiang,FENG Xiangdong,LI Yandong.A case of mucinous adrenocortical adenoma with pseudoadenoid structure ［J］.Journal of Diagnostic Pathology,2005,12(6):479．
[17] JANG K,CHUNG M,MOON W,et al.Adrenocortical adenoma with unusual myxoid histological pattern:a case report［J］.Pathology,2009,41(2):188-191．
[18] LU HS,GAN MF,CHEN HS,et al.Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome［J］.J Zhejiang Univ Sci B,2008,9(6):500-505.
[19] ZENG Z,GU LJ,ZHOU ZY,et al.Myxoid adrenocortical adenoma with a pseudoglandular pattern:A case report and literature review［J］.Int J Clin Exp Pathol,2017,10(8):8908-8915.
[20] PAPOTTI M,VOLANTE M,DUREGON E,et al.Adrenocortical tumors with myxoid features:a distinct morphologic and phenotypical variant exhibiting malignant behavior［J］.Am J Surg Pathol,2010,34(7):973-983.
[21] WEISSFERDT A,PHAN A,SUSTER S,et al.Myxoid adreno-cortical carcinoma:a clinicopathologic and immunohistochemical study of 7 cases,including 1 case with lipomatous metaplasia［J］.Am J Clin Pathol,2013,139(6):780-786.

Memo

Memo:
皖南医学院重点项目研究（编号：WK2016208）
Last Update: 2021-12-02