|Table of Contents|

FERMT1 expression and significance in bladder carcinoma tissues by bioinformatics analysis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2022 01
Page:
71-76
Research Field:
Publishing date:

Info

Title:
FERMT1 expression and significance in bladder carcinoma tissues by bioinformatics analysis
Author(s):
GUO Xiaohui1; 2; 3; LI Ce1; 2; 3; GONG Libao1; 2; 3; LI Yatian1; 2; 3; CHE Xiaofang1; 2; 3; QU Xiujuan1; 2; 3
1.Department of Medical Oncology;2.Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province，the First Hospital of China Medical University,Liaoning Shenyang 110001;3.Liaoning Province Clinical Research Center for Cancer，Liaoning Shenyang 110
Keywords:
bladder carcinoma; FERMT1; bioinformatics analysis; prognosis
PACS:
R737.14
DOI:
10.3969/j.issn.1672-4992.2022.01.016
Abstract:
Objective:To analyze the expression level of FERMT1 in bladder cancer and its relationship with pathological parameters by bioinformatics,and to mine its mutation information and regulatory network.Methods:Firstly,the GEPIA database was used to analyze the expression level of FERMT1 in multiple cancers,and then online websites such as Oncomine and THPA were used to analyze the mRNA and protein expression of FERMT1 gene in bladder cancer.The online UALCAN database was used to show the relationship between FERMT1 and clinicopathological parameters relationship.cBioPortal online database analyzed the mutation of FERMT1 gene.LinkedOmics software explored the genes co-expressed with FERMT1 and gene enrichment analysis.Results:FERMT1 was highly expressed in most cancers，for bladder cancer,FERMT1 mRNA and protein levels were significantly up-regulated which was closely related to the clinicopathological parameters.At the same time,several types of copy number mutations occurred in FERMT1 gene,and missense mutations were the most common.FERMT1 co-expressed with a variety of genes,and further enrichment analysis shows that these genes played an important role in a variety of biological processes.Conclusion:This study effectively revealed the expression information and potential regulatory network of FERMT1 in bladder cancer,laying a theoretical foundation for further research on the role of FERMT1 in the development of bladder cancer.

References:

[1]BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries ［J］.CA:A Cancer Journal for Clinicians,2018,68(6):394-424.
[2]AGGEN D,DRAKE C.Biomarkers for immunotherapy in bladder cancer:a moving target ［J］.Journal for Immunotherapy of Cancer 2017,5(1):94.
[3]JOBARD F,BOUADJAR B,CAUX F,et al.Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome ［J］.Human Molecular Genetics,2003,12(8):925-935.
[4]瞿根义，汤乘，徐勇，等.基于癌症基因组图谱和Oncomine数据库膀胱尿路上皮癌生物信息学分析［J］.疑难病杂志,2020,19(8):823-827. QU GY,TANG C,XU Y,et al.Bioinformatics analysis of bladder urothelial carcinoma based on cancer genome map and oncomine database ［J］.Chinese Journal of Difficult and Complicated Cases,2020,19(8):823-827.
[5]刘洪军，漆建，尹久，等.基于Oncomine数据库及GEPIA数据库分析CHI3L2基因在胶质母细胞瘤中的表达及与预后的相关性［J］.现代肿瘤医学,2020,28(20):3506-3510. LIU HJ,QI J,YIN J,et al.Expression of CHI3L2 gene in glioblastoma based on Oncomine database and GEPIA da-tabase and its relationship with prognosis［J］.Modern Oncology,2020,28(20):3506-3510.
[6]郑帅，田国祥，韩迪迪，等.cBioPortal数据库介绍及数据提取流程［J］.中国循证心血管医学,2020,12(9):1028-1031. ZHENG S,TIAN GX,HAN DD,et al.cBioPortal satabase introduction and data extraction process［J］.Chinese Journal of Evidence-Bases Cardiovascular Medicine,2020,12(9):1028-1031.
[7]VASAIKAR S,STRAUB P,WANG J,et al.LinkedOmics:analyzing multi-omics data within and across 32 cancer types［J］.Nucleic Acids Research,2018,46:D956-D963.
[8]ROGNONI E,RUPPERT R,FSSLER R.The kindlin family:functions,signaling properties and implications for human disease ［J］.Journal of Cell Science,2016,129(1):17-27.
[9]CANNING C,CHAN J,COMMON J,et al.Developmental expression of the fermitin/kindlin gene family in Xenopus laevis embryos［J］.Developmental Dynamics,2011,240(8):1958-1963.
[10]ZHAN J,ZHU X,GUO Y,et al.Opposite role of Kindlin-1 and Kindlin-2 in lung cancers［J］.PLoS One,2012,7(11):e50313.
[11]HARRYMAN WL,POND E,SINGH P,et al.Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers［J］.American Journal of Translational Research,2016,8(2):940-954.
[12]RUAN S,LIN M,ZHU Y,et al.Integrin β4-targeted cancer immunotherapies inhibit tumor growth and decrease metastasis［J］.Cancer Research,2020,80(4):771-783.
[13]MARIATH L,SANTIN J,FRANTZ J,et al.An overview of the genetic basis of epidermolysis bullosa in Brazil:discovery of novel and recurrent disease-causing variants［J］.Clinical Genetics,2019,96(3):189-198.
[14]HARRYMAN W,POND E,SINGH P,et al.Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers［J］.American Journal of Translational Research,2016,8(2):940-954.
[15]YANG A,KAGHAD M,WANG Y,et al.p63,a p53 homolog at 3q27-29,encodes multiple products with transactivating,death-inducing,and dominant-negative activities［J］.Molecular Cell,1998,2(3):305-316.
[16]INOUE Y,KISHIDA T,KOTANI S,et al.Direct conversion of fibroblasts into urothelial cells that may be recruited to regenerating mucosa of injured urinary bladder［J］.Scientific Reports,2019,9(1):13850.
[17]KARNI-SCHMIDT O,CASTILLO-MARTIN M,SHEN T,et al.Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression［J］.The American Journal of Pathology,2011,178(3):1350-1360.

Memo

Memo:
“重大新药创制”科技重大专项（编号：2017ZX09304025）；辽宁省重点研发指导计划资源平台建设项目（编号：2018225060）
Last Update: 2021-12-02