|Table of Contents|

New strategies of cancer therapy based on ferroptosi

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2021 06
Page:
1058-1061
Research Field:
Publishing date:

Info

Title:
New strategies of cancer therapy based on ferroptosi
Author(s):
PANG JingyaoLI PeilingBeilerli AferinYAN YuWANG Jingmeng
Department of Gynecology,the 2nd Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150000,China.
Keywords:
ferroptosiscancer therapygenenanomaterialssmall molecules
PACS:
R730.5
DOI:
10.3969/j.issn.1672-4992.2021.06.034
Abstract:
Ferroptosis is a new form of regulatory cell death that relies primarily on cell death caused by intracellular iron and reactive oxygen species accumulation.Since its first introduction in 2012,it has attracted widespread attention in the fields of biochemistry,oncology,and materials science research.The process of interfering with cancer by activating or inhibiting cell iron death has become a new hot spot for cancer treatment,including small molecule compounds,nanomaterials and genetic technologies.This article mainly describes the current new strategies,advantages and limitations of cancer treatment based on iron death,and hopes to provide reference for cancer treatment.

References:

[1] DIXON SJ,LEMBERG KM,LAMPRECHT MR,et al.Ferroptosis:an iron-dependent form of nonapoptotic cell death [J].Cell,2012,149(5):1060-1072.
[2] XIE Y,HOU W,SONG X,et al.Ferroptosis:process and function [J].Cell Death and Differentiation,2016,23(3):369-379.
[3] ZILLE M,KARUPPAGOUNDER SS,CHEN Y,et al.Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis [J].Stroke,2017,48(4):1033-1043.
[4] NEITEMEIER S,JELINEK A,LAINO V,et al.BID links ferroptosis to mitochondrial cell death pathways [J].Redox Biology,2017,12:558-570.
[5] STOCKWELL BR,FRIEDMANN ANGELI JP,BAYIR H,et al.Ferroptosis:A regulated cell death nexus linking metabolism,redox biology,and disease [J].Cell,2017,171(2):273-285.
[6] YUAN H,LI X,ZHANG X,et al.Identification of ACSL4 as a biomarker and contributor of ferroptosis [J].Biochemical and Biophysical Research Communications,2016,478(3):1338-1343.
[7] CHENG Z,LI Y.What is responsible for the initiating chemistry of iron‐mediated lipid peroxidation:An update[J].Cheminform,2010,38(22).
[8]SEILER A,SCHNEIDER M,FORSTER H,et al.Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death [J].Cell Metabolism,2008,8(3):237-248.
[9] LUO M,WU L,ZHANG K,et al.miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma [J].Cell Death and Differentiation,2018,25(8):1457-1472.
[10] SHEN Z,SONG J,YUNG BC,et al.Emerging strategies of cancer therapy based on ferroptosis [J].Advanced Materials,2018,30(12):e1704007.
[11] YU H,GUO P,XIE X,et al.Ferroptosis,a new form of cell death,and its relationships with tumourous diseases [J].Journal of Cellular and Molecular Medicine,2017,21(4):648-657.
[12] XIE Y,ZHU S,SONG X,et al.The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity [J].Cell Reports,2017,20(7):1692-1704.
[13] SUN X,OU Z,CHEN R,et al.Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells [J].Hepatology,2016,63(1):173-184.
[14] YAGODA N,VON RECHENBERG M,ZAGANJOR E,et al.RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels [J].Nature,2007,447(7146):864-868.
[15] KANG R,KROEMER G,TANG D.The tumor suppressor protein p53 and the ferroptosis network [J].Free Radical Biology & Medicine,2019,133:162-168.
[16] TARANGELO A,MAGTANONG L,BIEGING-ROLETT KT,et al.p53 suppresses metabolic stress-induced ferroptosis in cancer cells [J].Cell Reports,2018,22(3):569-575.
[17] SUN X,NIU X,CHEN R,et al.Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis [J].Hepatology,2016,64(2):488-500.
[18] WANG Z,DING Y,WANG X,et al.Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT [J].Cancer Letters,2018,428:21-33.
[19] RECALCATI S,GAMMELLA E,CAIRO G.Dysregulation of iron metabolism in cancer stem cells [J].Free Radical Biology & Medicine,2019,133:216-220.
[20] RUBIO-NAVARRO A,CARRIL M,PADRO D,et al.CD163-macrophages are involved in rhabdomyolysis-induced kidney injury and may be detected by MRI with targeted gold-coated iron oxide nanoparticles [J].Theranostics,2016,6(6):896-914.
[21] ZANGANEH S,HUTTER G,SPITLER R,et al.Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues [J].Nature Nanotechnology,2016,11(11):986-994.
[22] MA P,XIAO H,YU C,et al.Enhanced cisplatin chemotherapy by iron oxide nanocarrier-mediated generation of highly toxic reactive oxygen species [J].Nano Letters,2017,17(2):928-937.
[23] ZHOU Z,SONG J,TIAN R,et al.Activatable singlet oxygen generation from lipid hydroperoxide nanoparticles for cancer therapy [J].Angewandte Chemie,2017,56(23):6492-6496.
[24] LI WP,SU CH,CHANG YC,et al.Ultrasound-induced reactive oxygen species mediated therapy and imaging using a fenton reaction activable polymersome [J].ACS Nano,2016,10(2):2017-2027.
[25] ZHANG C,BU W,NI D,et al.Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized fenton reaction [J].Angewandte Chemie,2016,55(6):2101-2106.
[26] ZHENG DW,LEI Q,ZHU JY,et al.Switching apoptosis to ferroptosis:Metal-organic network for high-efficiency anticancer therapy [J].Nano Letters,2017,17(1):284-291.
[27] YUE L,WANG J,DAI Z,et al.pH-responsive,self-sacrificial nanotheranostic agent for potential in vivo and in vitro dual modal MRI/CT imaging,real-time,and in situ monitoring of cancer therapy [J].Bioconjugate Chemistry,2017,28(2):400-409.
[28] KIM SE,ZHANG L,MA K,et al.Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth [J].Nature Nanotechnology,2016,11(11):977-985.
[29] JIANG L,KON N,LI T,et al.Ferroptosis as a p53-mediated activity during tumour suppression [J].Nature,2015,520(7545):57-62.
[30] DOLL S,PRONETH B,TYURINA YY,et al.ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition [J].Nature Chemical Biology,2017,13(1):91-98.
[31] YUAN H,LI X,ZHANG X,et al.CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation [J].Biochemical and Biophysical Research Communications,2016,478(2):838-844.
[32] SUN X,OU Z,XIE M,et al.HSPB1 as a novel regulator of ferroptotic cancer cell death [J].Oncogene,2015,34(45):5617-5625.
[33] TORII S,SHINTOKU R,KUBOTA C,et al.An essential role for functional lysosomes in ferroptosis of cancer cells [J].The Biochemical Journal,2016,473(6):769-777.

Memo

Memo:
-
Last Update: 1900-01-01