|Table of Contents|

Correlation between the occurrence and development of cervical intraepithelial neoplasia and the co-expression of p16/Ki-67

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
1032-1035
Research Field:
Publishing date:

Info

Title:
Correlation between the occurrence and development of cervical intraepithelial neoplasia and the co-expression of p16/Ki-67
Author(s):
Yin Lu1; Zheng Leizhen2; Ma Chengbin1; Zhao Xuejun3
1.Obstetrics and Gynecology Department;3.Pathology Department，Shanghai Changning District Maternal and Child Health Hospital,Shanghai 200051,China;2.Oncology Department，Xinhua Hospital Affiliated to Medical College of Shanghai Jiaotong University,Shanghai
Keywords:
cervical intraepithelial neoplasia; p16/Ki-67; double staining; correlation
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2020.06.036
Abstract:
Cervical intraepithelial neoplasia (CIN) belongs to a cervical precancerous lesion.Although it takes a long time for CIN to progress into cervical cancer,its incidence is increased and the age of onset is small,which causes serious impact on physical and mental health of women.p16 is considered to be the earliest discovery of tumor suppressor genes and plays an important role in the differential diagnosis of low-grade and high-grade cervical squamous intraepithelial lesions.Ki-67 is a common tumor marker and is expressed in a variety of tumors.p16/Ki-67 double staining is a new method for screening or diagnosing cervical lesions,that is,the co-expression of p16 and Ki-67 in the same cell indicates that the cell cycle is disordered,and high-grade tumor-like lesions in the cervical epithelium are considered.The role of p16 and Ki-67 in CIN has been reported,but no relevant review has been reported.In this study,the correlation between CIN and co-expression of p16/Ki-67 was reviewed to provide references for identification and diagnosis of cervical lesions.

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上海市长宁区科学技术委员会项目计划（编号：CNKW2016Y12）
Last Update: 2020-01-21