|Table of Contents|

Curative effect of multiple myeloma complicated with acute renal injury treatment by CVVH and hemoperfusion

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
1015-1019
Research Field:
Publishing date:

Info

Title:
Curative effect of multiple myeloma complicated with acute renal injury treatment by CVVH and hemoperfusion
Author(s):
Zhuang Jing; Du Heng; Lu Chen
Nephropathy Department,People's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Urumqi 830001,China.
Keywords:
CVVH; hemoperfusion; multiple myeloma; acute kidney injury
PACS:
R733.3
DOI:
10.3969/j.issn.1672-4992.2020.06.031
Abstract:
Objective：To observe the curative effect of multiple myeloma （MM） complicated with acute kidney injury （AKI） treatment by continuous veno-venous hemofiltration (CVVH) and hemoperfusion (HP).Methods:68 patients with MM combined with AKI admitted to our hospital from May 2017 to May 2018 were enrolled in the study.According to the random number table method,the patients in the control group (34 cases) were treated with bortezomib,melphalan and prednisone.The patients in the observation group (34 cases) were treated with CVVH combined with HP on the basis of the control group.To observe and compare the therapeutic effect,the changes of renal function injury and related indicators of the two groups before and after treatment.Results:The total effective rate of the observation group (82.35%) was higher than that of the control group (55.88%) (P＜0.05).After treatment,the levels of BUN,SCr,β2-MG and CysC in the two groups were lower than those before treatment (P＜0.05),and the above indexes in observation group were significantly lower than those in control group (P＜0.05).After treatment,the level of M protein and the percentage of myeloma cells in both groups were significantly lower than before treatment,and the level of hemoglobin was significantly higher than before treatment (P＜0.05),and the improvement of observation group was more significant than that of control group (P＜0.05).After treatment,there was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion:CVVH combined with hemoperfusion can improve the therapeutic effect of multiple myeloma patients with acute kidney injury,reduce renal function damage,and have good safety.

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Memo

Memo:
新疆维吾尔自治区自然科学基金项目（编号：2017D01C160）
Last Update: 2020-02-10