|Table of Contents|

The expression and significance of XB130 in Bowen' s disease and the clinicalpathological observation

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
994-997
Research Field:
Publishing date:

Info

Title:
The expression and significance of XB130 in Bowen' s disease and the clinicalpathological observation
Author(s):
Huang Yingjian; Wang Ning; Duan Qiqi; Wang Shengbang; Liu Meng; Kang Tong; Luo Ruiting; Zheng Yan
Department of Dermatology,the Second Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710004,China.
Keywords:
XB130; Bowen's disease; clinical pathological features; immunohistochemistry
PACS:
R739.5
DOI:
10.3969/j.issn.1672-4992.2020.06.026
Abstract:
Objective：To investigate the expression and significance of XB130 in Bowen's disease and analyze the clinical pathological characteristics of the patients.Methods:Immunohistochemistry was carried out to detect the expression of XB130 in 37 patients with Bowen's disease and 35 specimens of normal skin.Retrospective analysis was conducted to analyze the clinical pathological characteristics of 161 patients with Bowen's disease.Results:There was no significant difference in sex ratioin 161 patients from 2012 to 2018,but the mean age of diagnosis of male and female patients was statistically different.The most common anatomical site of the patients was trunk.XB130 was down-regulated in Bowen's disease.The positive rate and expression intensity of XB130 were both statistically significant between normal skin and Bowen's disease (P＜0.05).Conclusion:The age of onset of males is earlier than that of females,but there is no difference in sex ratio.The high incidence age of patients is in the old age.Head and neck region was the anatomical site most frequently observed in female patients,whereas trunk was the most represented location in male patients.And the most common site of the overall patients was trunk.The expression of XB130 in Bowen's disease was significantly lower than that of normal skin.XB130 may be involved in the pathogenesis of Bowen's disease.

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Memo

Memo:
National Natural Science Foundation of China（No.81573055）;国家自然科学基金资助项目（编号：81573055）
Last Update: 2020-02-10