|Table of Contents|

Prognostic value of systemic inflammatory response combined with tumor immunological score in patients with liver metastases from colorectal cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
984-988
Research Field:
Publishing date:

Info

Title:
Prognostic value of systemic inflammatory response combined with tumor immunological score in patients with liver metastases from colorectal cancer
Author(s):
Song Yu1Zhang Lin1Wang Guanghui1Chen Ming2
1.General Surgery,First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China;2.Department of Hepatobiliary Surgery,Shengjing Hospital Affiliated to China Medical University,Liaoning Shenyang 110004,China.
Keywords:
systemic inflammatory responsetumor immune scorecolorectal cancerliver metastasis
PACS:
R735
DOI:
10.3969/j.issn.1672-4992.2020.06.024
Abstract:
Objective:To analyze the prognostic value of systemic inflammatory response combined with tumor immune score in patients with liver metastasis of colorectal cancer.Methods:From January 2014 to January 2016,105 patients treated in our hospital for colorectal cancer liver metastasis disease were selected as research objects.All patients were followed up for 3 years after surgery.Systematic inflammatory response score and tumor immune score were used to evaluate the postoperative prognosis of patients,and to evaluate the prognostic value of systematic inflammatory response combined with tumor immune score in patients with liver metastasis of colorectal cancer.Results:Under the mGPS score,the 3-year overall survival rate of group 0 was higher than that of group 1 and group 2 (P<0.05).With respect to the immune score of the primary lesion,the 3-year overall survival rate of the 5 groups presented a gradually increasing trend from low score to high score (P<0.05).There was no significant difference in overall survival rate at 3 years after operation in the 5 groups under LM immune score (P>0.05).Under combined scores,the 3-year overall survival rate of high-risk group was significantly lower than that of low-risk group (35.2% vs 84.3%)(P<0.05).The predictive value of systemic inflammatory response combined with tumor immune score for OS after CRLM surgery was relatively high.When the cut-off value was 1.8,the AUC was 0.796,the sensitivity was 73.94%,and the specificity was 87.56%.Conclusion:Systemic inflammatory response combined with tumor immunological score is more accurate in the postoperative outcome of patients with liver metastases from colorectal cancer,and the predictive value is higher.It provides scientific and favorable data support for the development and improvement of follow-up treatment plan,and the clinical application value is significant.

References:

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Memo

Memo:
陕西省社会发展科技攻关项目(编号:2015SF057)
Last Update: 2020-01-21