|Table of Contents|

RNA binding protein QKI-5 effect on the proliferation and cell cycle of renal cancer cell

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 06
Page:
871-876
Research Field:
Publishing date:

Info

Title:
RNA binding protein QKI-5 effect on the proliferation and cell cycle of renal cancer cell
Author(s):
Zhang Ruili1; 2; Dou Yanran2; Ainiwaer·Aimudula2; Xiong Jian1; Bao Yongxing2
1.Postdoctoral Workstation,Changji Branch Hospital of the First Affiliated Hospital of Xinjiang Medical University,Xinjiang Changji 831100,China;2.Cancer Center,the First Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830054,China.
Keywords:
QKI-5; RCC; cell cycle
PACS:
R737.12
DOI:
10.3969/j.issn.1672-4992.2020.06.001
Abstract:
Objective：To analyze the function of QKI-5 in renal cell carcinoma（RCC).Methods:Overexpression technique using lentivirws as a vector detected the effect of overexpressing QKI-5 on proliferation and cell cycle of RCC.Results:In vitro assays revealed that the ectopic expression of QKI-5 effectively inhibited cellular proliferation,resulting in significant inhibition of the cellular growth rate and reduction in the colony forming ability of the cells.Moreover,ectopic expression of QKI-5 in 786-O and A-498 cells significantly increased the proportion of cells in G1 phase and decreased the proportion in S phase and displayed a reduction in Cyclin D1 and an accumulation of p21 and p27.Conclusion:Our data establish a suppressive role for QKI-5 in RCC tumourigenesis.

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Memo

Memo:
National Natural Science Foundation of China（No.81760452）;国家自然科学基金项目(编号：81760452）；国家级课题第62批中国博士后基金面上项目二等资助（编号：2017M623338XB）
Last Update: 2020-01-21