|Table of Contents|

The research progress of neoantigens in precise cellular immunotherapy

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 05
Page:
847-850
Research Field:
Publishing date:

Info

Title:
The research progress of neoantigens in precise cellular immunotherapy
Author(s):
Jing Yumeng1Zhao Haichao2Xiao Hong3
1.The First Clinical Medical College of Shanxi Medical University,Shanxi Taiyuan 030001,China;2.Shanxi Bethune Hospital of Shanxi Medical University,Shanxi Taiyuan 030001,China;3.Pathology Department,First Hospital of Shanxi Medical University,Shanxi Taiyuan 030001,China.
Keywords:
neoantigensepitope peptideprecision cell immunotherapy
PACS:
R730.51
DOI:
10.3969/j.issn.1672-4992.2020.05.037
Abstract:
How to use the cell surface antigen to distinguish the immune system from normal cells and cancer cells is the key to tumor cell immunotherapy.The latest technology has led people to understand that the mutation of tumor cells produces new epitope peptides,which in turn cause specific immune responses in patients,and the latest research shows that the identification of neoantigens of this tumor will become important for clinical immunotherapy breaking point.The results show that,in cancer immunotherapy,tumor neoantigens can be used as a biomarker to develop and enhance the reactivity against such antigen-selective T cells,providing hope for new immunotherapy.Precision cell immunotherapy (PCIT) uses high-throughput gene sequencing and big data analysis to obtain precise T cells for neoplasm (PNA-T),and then enrich PNA-T for precise cellular immunotherapy of cancer patients.

References:

[1]Martinez-Lopez A,Almazan-Fernandez FM,Perez-Lopez I,et al.Successful treatment of cutaneous metastatic melanoma with high-dose intralesional interleukin-2 treatment combined with cryosurgery[J],Dermatol Ther,2018(15):1-3.
[2]Gubin MM,Zhang X,Schuster H,et al.Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens[J].Nature,2014,515(7528):577-581.
[3]Yadav M,Jhunjhunwala S,Phung QT,et al.Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing[J].Nature,2014,515(7528):572-576.
[4]Larbcharoensub N,Mahaprom K,Jiarpinitnun C,et al.Characterization of PD-L1 and PD-1 expression and CD8+ tumor-infiltrating lymphocyte in ePstein-Barr virus-associated nasopharyngeal carcinoma[J].American Journal of Clinical Oncology,2018,41(12):1204-1210.
[5]Linnemann C,van Buuren MM,Bies L,et al.High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma[J].Nature Medicine,2015,21(1):81-85.
[6]Palodhi A,Ghosh S,Biswas NK,et al.Profiling of genomic alterations of mitochondrial DNA in gingivobuccal oral squamous cell carcinoma:Implications for disease progress[J].Mitochondrion,2018,24(6):1-27.
[7]Hundal J,Kiwala S,Feng YY,et al.Accounting for proximal variants improves neoantigen prediction[J].Nature Genet,2018,2(3):771-779.
[8]Mirjana E,Francesca F,Dietmar R,et al.Neoantigens generated by individual mutations and their role in cancer immunity and immunotherapy[J].Frontiers in Immunology,2017,8(1):1679-1687.
[9]Abedalthagafi M.Constitutional mismatch repair-deficiency:current problems and emerging therapeutic strategies[J].Oncotarget,2018,9(83):106-119.
[10]Wu J,Zhao W,Zhou B,et al.TSNAdb:A database for tumor-specific neoantigens from immunogenomics data analysis[J].Genomics,Proteomics & Bioinformatics,2018,16(4):21-30.
[11]Koalolu-Yalin Z,Lanka M,Frentzen A,et al.Predicting T cell recognition of MHC class I restricted neoepitopes[J].Oncoimmunology,2018,7(11):201-238.
[12]Blaha DT,Anderson SD,Yoakum DM,et al.High-throughput stability screening of neoantigen/HLA complexes improves immunogenicity predictions[J].Cancer Immunol Res,2018,15(3):12-41.
[13]Kinkead HL,Hopkins A,Lutz E,et al.Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer[J].JCI Insight,2018,3(20):e1-e15.
[14]Duan F,Duitama J,Al Seesi S,et al.Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity[J].J Exp Med,2014,211(11):2231-2248.
[15]Marty R,Thompson WK,Salem RM,et al.Evolutionary pressure against MHC class Ⅱ binding cancer mutations[J].Cell,2018,175(2):416-428.
[16]Fridman WH.From cancer immune surveillance to cancer immunoediting:Birth of modern immuno-oncology[J].J Immunol,2018,201(3):825-826.
[17]Aragon-Sanabria V,Kim GB,Dong C,et al.From cancer immunoediting to new strategies in cancer immunotherapy:The roles of immune cells and mechanics in oncology[J].Adv Exp Med Biol,2018(092):113-138.
[18]Martin SD,Wick DA,Nielsen JS,et al.A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer[J].Oncoimmunology,2018,7(1).doi:10.1080/2162402X.2017.1371895.
[19]O' Donnell JS,Teng MWL,Smyth MJ,et al.Cancer immunoediting and resistance to T cell-based immunotherapy[J].Nat Rev Clin Oncol,2018,5(21):e1-e17.
[20]Efremova M,Rieder D,Klepsch V,et al.Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution[J].Nature Communications,2018,9(1):32-45.
[21]MS Rooney,SA Shukla,CJ Wu,et al.Molecular and genetic properties of tumors associated with local immune cytolytic activity[J].Cell,2015,160(1-2):48-61.
[22]Deniger DC,Pasetto A,Tran E,et al.Stable,non-viral expression of mutated tumor neoantigen-specific T-cell receptors using the Sleeping Beauty transposon/transposase system[J].Molecular Therapy,2016,24(6):1078-1089.
[23]Li L,Goedegebuure SP,Gillanders WE.Preclinical and clinical development of neoantigen vaccines[J].Annals of Oncology,2017,28(suppl_12):xii11-xii17.
[24]Yi M,Qin S,Zhao W,et al.The role of neoantigen in immune checkpoint blockade therapy[J].Exp Hematol Oncol,2018,7(1):28-39.
[25]Ott PA,Hu Z,Keskin DB,et al.An immunogenic personal neoantigen vaccine for patients with melanoma[J].Nature,2017,547(7662):217.
[26]Sahin U,Derhovanessian E,Miller M,et al.Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer[J].Nature,2017,547(7662):222-226.
[27]Lu YC,Zheng Z,Robbins PF,et al.An efficient single-cell RNA-seq approach to identify neoantigen-specific T cell receptors[J].Molecular Therapy,2018,26(2):379-389.
[28]Terhi K,Johanna O.The potential of donor T-cell repertoires in neoantigen-targeted cancer immunotherapy[J].Frontiers in Immunology,2017(8):1718-1742.
[29]Wilson EA,Anderson KS.Lost in the crowd:identifying targetable MHC class I neoepitopes for cancer immunotherapy[J].Expert Rev Proteomics,2018,15(12):1065-1077.
[30]Strnen E,Toebes M,Kelderman S,et al.Targeting of cancer neoantigens with donor-derived T cell receptor repertoires[J].Science,2016,352(6291):1337-1341.
[31]Wirth TC,Kühnel F.Neoantigen targeting-dawn of a new era in cancer immunotherapy[J].Frontiers in Immunology,2017(8):1848.

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