|Table of Contents|

The role of combined detection of preoperative serum CA125，HE4 and neutrophil-lymphocyte ratio in the diagnosis of endometrial cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 05
Page:
792-795
Research Field:
Publishing date:

Info

Title:
The role of combined detection of preoperative serum CA125，HE4 and neutrophil-lymphocyte ratio in the diagnosis of endometrial cancer
Author(s):
Zhang Huiling; Lv Yanguan
Department of Clinical Laboratory，Yangzhou University Affiliated Huai'an Maternal and Child Health Hospital，Jiangsu Huai'an 223001，China.
Keywords:
CA125; HE4; NLR; endometrial cancer
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2020.05.022
Abstract:
Objective：To investigate the clinical value of serum carbohydrate antigen 125 （CA125），human epididymis protein 4 （HE4） and neutrophil-lymphocyte ratio （NLR） in the diagnosis of endometrial cancer.Methods：42 patients with endometrial cancer，50 patients with endometrial benign disease and 50 healthy people were selected.Neutrophil and lymphocyte counts in peripheral blood were determined by SYSMEX XN550 automatic hematology analyzer，and NLR was calculated.The levels of preoperative serum CA125 and HE4 were determined by Maglumi4000 automatic chemiluminescence analyzer.ROC curve was used to analyse role of CA125，HE4，NLR and the combination of the three in the diagnosis of endometrial cancer.Results：Peripheral blood NLR was increased gradually in the healthy group，benign group and endometrial cancer group(P<0.05).The expression of serum HE4 in the endometrial cancer group was significantly higher than that in the benign group and the healthy group(P<0.05)，but there was no significant difference between the benign group and the healthy group (P>0.05).There was no significant difference in serum CA125 expression in the three groups (P>0.05).The AUC of CA125，HE4，NLR and the three combined markers was 0.530，0.733，0.795，0.823，respectively.When their cut-off values were taken，the specificity was 70.8%，85.1%，61.7%，83.0%，respectively，and the sensitivity was 40.0%，63.3%，86.7%，73.3%.The sensitivity of NLR was higher than CA125，HE4，but the specificity of HE4 was most highest.The combined markers had high specificity and sensitivity.Conclusion：The combined detection of preoperative serum CA125，HE4 and NLR has high specificity and sensitivity，which can guide the diagnosis of endometrial cancer，improve the accuracy of clinical diagnosis of endometrial cancer.

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