|Table of Contents|

Prognostic value analysis of ANGPT1 and the expression of ANGPT1 in lung adenocarcinoma tissues

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 04
Page:
587-591
Research Field:
Publishing date:

Info

Title:
Prognostic value analysis of ANGPT1 and the expression of ANGPT1 in lung adenocarcinoma tissues
Author(s):
Cheng Yang1; Wang Yizhe1; Jin Yue2; 3; Bao Bowen2; 3; Zheng Chunlei2; 3; Hou Kezuo2; 3; Che Xiaofang2; 3; Hu Xuejun1
1.Department of Respiratory and Infectious Disease of Geriatrics;2.Department of Medical Oncology;3.Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province,the First Hospital of China Medical University,Liaoning Shenyang 110001,China.
Keywords:
lung adenocarcinoma; ANGPT1; data analysis; prognosis
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.04.014
Abstract:
Objective：To investigate the prognostic significance of angiopoietin 1（ANGPT1) and the exprssion of ANGPT1 in lung adenocarcinoma tissues.Methods:Data of lung adenocarcinoma and lung squamous cell carcinoma with the ANGPT1 gene expression profile data and clinical information were downloaded from the Cancer Genome Atlas（TCGA) database.The difference of ANGPT1 expression in lung cancer tissues and normal tissues was determined by t test.The correlation between ANGPT1 gene expression and clinicopathological features of lung adenocarcinoma patients was analyzed by χ2 test.Log-rank test was used for survival analysis.To predict the pathways that may be regulated by ANGPT1 in lung adenocarcinoma,Gene Set Enrichment Analysis（GSEA) method was used for gene set enrichment analysis.Results:The mRNA level of ANGPT1 in lung cancer tissues was lower than that in normal tissues.Its expression level was negatively correlated with T stage（P=0.013).Patients with low-expression ANGPT1 lung adenocarcinoma had significantly worse prognosis than those with high expression（P=0.006).ANGPT1 was an independent protective factors for adenocarcinoma prognosis（P＜0.05).GSEA results showed that ANGPT1 might affect the development of lung adenocarcinoma by regulating G2M checkpoints,DNA damage repair,apoptosis,and cell proliferation-related pathways such as mTOR signaling,MYC signaling and mitotic spindle.Conclusion:ANGPT1 is an independent prognostic factor for lung adenocarcinoma and might be as a potential prognostic biomarker and therapeutic target for lung adenocarcinoma.

References:

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Memo

Memo:
National Natural Science Foundation of China（No.81472193）;国家自然科学基金资助项目（编号:81472193）；辽宁省重点研发指导计划资源平台建设项目（编号：2018225060）
Last Update: 2019-12-26