|Table of Contents|

The value of muiti-b DWI in evaluating the efficacy of radiotherapy and chemotherapy in cervical cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 02
Page:
268-271
Research Field:
Publishing date:

Info

Title:
The value of muiti-b DWI in evaluating the efficacy of radiotherapy and chemotherapy in cervical cancer
Author(s):
Huang Wenliang; Zhou Shan; Wu Shufen
Department of MRI,the Second Affiliated Hospital of Luohe Medical College，Henan Luohe 462300,China.
Keywords:
cervical cancer; muiti-b diffusion-weighted imaging; apparent diffusion coefficient; radiochemotherapy
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2020.02.021
Abstract:
Objective:To Explore the efficecy of muiti-b magnetic resonance diffusion weighted imaging in the response of cervical cancer to concurrent radiochemotherapy.Methods：Fifty-one patients with advanced cervical cancer underwent conventional MRI and DWI examinations before therapy and after the initiation of concurrent radiochemotherapy.The longest diameter of tumor before and after treatment was measured.The ADC was calculated,compared and correlated with final tumour retracton.Results:The ADC value of cervical cancer after radiochemotherapy was increased.The ADC values of prior to radiochemotherapy,2~3 weeks and after the adiochemotherapy was（0.81±0.13）×10-3 mm2/s,（1.18±0.14）×10-3 mm2/s,（1.47±0.22）×10-3 mm2/s.It showed significant difference each other(P＜0.01)．The change of ADC between prior to radiochemotherapy,2~3 weeks therapy was（0.37±0.12)×10-3 mm2/s.Final tumor retraction was 0.78±0.11,no correlation was foud between ADC values and tumour,while the changes in ADC showed a significant correlation with tumour retraction(P＜0.05).Conclusion:The ADC values of cervical cancer increased after radiochemotherapy.The early change of ADC value showed a correlation with final tumour retraction,which will be an ieal tool to predicte the response of cervical cancer to concurrent radiochemotherapy．

References:

［1］ BAI Lu,LI Wenhui,CHEN Biliang.Current status and controversy of neoadjuvant chemotherapy for cervical cancer ［J］.Modern Oncology,2019,27（7）:1278-1280.［白璐，李雯慧，陈必良.宫颈癌新辅助化疗的现状与争议［J］.现代肿瘤医学,2019,27（7）:1278-1280.］
［2］HAO Xiaoning,WANG Xuan,GUO Xinghua.Evaluating the efficacy of neoadjuvant chemotherapy with magnetic resonance imaging in cervical cancer［J］.Chinese Remedies & Clinic,2015,15(6):802-804.［郝晓宁,王煊,郭兴华.磁共振成像在宫颈癌新辅助化疗疗效评价应用［J］.中国药物与临床,2015,15(6):802-804.］
［3］XING Qingna,ZHANG Xiaoan,ZHAO Xin，et al.The diagnostic value of diffusion weighted imaging in endometrial cancer［J］.J Clin Radiol,2014,33(1):69-73.［邢庆娜,张小安,赵鑫,等.磁共振扩散加权成像对子宫内膜癌的诊断价值［J］.临床放射学杂志,2014,33(1):69-73.］
［4］ZHAO Bo,CAO Kun.MR DWI evaluation on efficacy of radiotherapy and chemotherapy of cervical cancer［J］.Chin J Interv Imaging Ther,2018,15(12)：757-760.［赵博,曹崑.MR DWI评价宫颈癌放化疗效果中国介入影像与治疗学［J］.2018,15（12）：757-760.］
［5］BAI Yang.The stuy of magnetic resonance diffusion-weighted imaging in diagnosis and neoadjuvant chemotherapy incervical cancer［J］.Contemporary Medicine,2018,24(15):125-126.［白杨.磁共振扩散加权成像在宫颈癌诊断及新辅助化疗中的动态监测价值［J］.当代医学,2018,24(15):125-126.］
［6］ WU Bin,HUANG Xiao,PENG Weijun,et al.Value of MR diffusion weighted imaging in diagnosis and outcom prediction prediction for uterine cervical cancer［J］.Chin J Oncol,2014,36(2):115-119.［吴斌,黄啸,彭卫军,等.磁共振扩散加权成像在宫颈癌诊断和疗效预测中的价值［J］.中华肿瘤杂志,2014,36(2):115-119.］
［8］CHEN Bo,LV Furong.Advances in the study of magnetic resonance diffusion-weighted imaging in normal uterus and uterrine diaeases［J］.Chongqing Medicine,2014,43(27):3657-3659.［陈波,吕富荣.磁共振扩散加权成像在正常子宫及子宫疾病中的研究进展［J］.重庆医学,2014,43(27):3657-3659.］
［9］ YANG Jian,LI Chenxia,WANG Supin.Present research situation of magnetic resonance diffussion kurtosis imaging ［J］.Journal of Practical Radiology,2013,29(1): 133-135.［杨健,李晨霞,王素品.磁共振扩散峰度成像的研究现状［J］.实用放射学杂志,2013,29(1):133-135.］
［10］SU Wenjing，ZHU Chunzhi.Study on the effect of multi-mode MRI examinnation on cervical cancer diagnosis and radiotherapy［J］.Women＇s Health Research,2018,12(14):174-175.［苏文静,朱春枝.多模态ＭＲＩ检查对宫颈癌诊断与放疗疗效探究中［J］.外女性健康研究,2018,12(14):174-175.］
［11］ ZHANG Jie,WANG Yanping,LIN Ruizhen,et al.Value of multi-b-value DWI imaging combined with DCE-MRI in staging and assessment about chemo-radiotherapy of cervical cancer［J］.Clin Radiol,2017,36（8）:1150-1155.［张洁，王艳萍，林瑞贞,等.多b值磁共振扩散加权成像及动态增强扫描在宫颈癌临床分期及疗效评价中的初步研究［J］.临床放射学杂志，2017,36（8）:1150-1155.］
［12］ LIU Zhenguo，XU Yan，LI Jianyi,et al.The curative effect observation of multi-b-value diffusion weighted magnetic resonance (MRI) imaging in cervical cancer radiotherapy followed［J］.Clinical Research and Practice,2016，1（20）:147-148［刘振国，许琰，李建宜，等.磁共振多 b值弥散加权成像在宫颈癌放疗随访疗效观察［J］.临床医学研究与实践,2016，1（20）:147-148.］
［13］ LIU Lu，FAN Xiaoli,NIU Xiaoling,et al.Correlation between parameters of magnetic resonance diffusion weighted imaging and histological features of cervical carcinoma ［J］.Modern Oncology,2017,25(2):1987-1991.［刘鲁,范晓黎,牛晓玲,等.磁共振扩散加权成像参数与宫颈癌组织学特点的相关性［J］.现代肿瘤医学,2017,25(2):1987-1991.］
［14］Wang N,Zhan T,Ke T,et al.Increased expression of RRM2 by human papillomavirus E7 oncoprotein promotes angiogenesis in cervical cancer［J］.Br J Cancer,2014,110(4):1034-1044.
［15］LI Jie.Ralationship between VEGF and microvessel density in cervical cancer and HPV infectionr［J］.Metnral and Child Health Care of China,2015,30(2):295-299.［李杰.宫颈癌组织中VEGF 和微血管密度与HPV感染的关系［J］.中国妇幼保健,2015,30(2):295-299.］
［16］ZHOU Yong,YU Yingying,GUO Yunquan,et al.Study on correlations between CT perfusion imaging and changes of VEGF and MVD expressions of cervical cancer［J］.Journal of Medical Imaging,2015,25(2):299-303.［周永,余莹莹,郭云泉,等.宫颈癌 CT 灌注成像与VEGF、MVD 的相关性研究［J］.医学影像学杂志,2015,25(2):299-303.］
［17］CHEN Wenlin，XU Mingjing，LI Shaodong.Predictive value of texture analysis based on MＲI diffusion-weighted imaging for early recurrence of cervical cancer after surgery［J］.Guangxi Medical Journal，2018,40(13):1440-1443.［陈文林,胥明婧,李绍东.磁共振扩散加权成像纹理分析在对宫颈癌术后早期复发的预测价值［J］.广西医学,2018,40(13):1440-1443.］
［18］ZHOU Hongmei,XU Xiangyang,GONG Ping,et al.Application of MDCE-MRI and DWI quantitative parameters combined with SCCA in diagnosis and evaluation of cervical cancer［J］.Maternal and Child Health Care of China，2018，33（17）：4031-4032.［周红梅，徐向阳，龚萍,等.MDCE－MRI、DWI 定量参数联合 SCCA 在宫颈癌诊断和疗效评估中的应用［J］.中国妇幼保健，2018，33（17）：4031-4032.］

Memo

Memo:
漯河医学高等专科学校临床资助项目（编号：2015-S-LMC018）
Last Update: 2019-11-29