|Table of Contents|

Clinical pathological features and endoscopic presentation of gastric neuroendocrine neoplasms

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 02
Page:
260-264
Research Field:
Publishing date:

Info

Title:
Clinical pathological features and endoscopic presentation of gastric neuroendocrine neoplasms
Author(s):
Bai Bing1; Cang Shundong1; Kan Yunzhen2; Wen Yiyang1; Kuang Shengli3
1.Department of Oncology;2.Department of Pathology;3.Department of Digestive,Henan Provincial People's Hospital (People's Hospital of Zhengzhou University),Henan Zhengzhou 450003,China.
Keywords:
gastric neuroendocrine neoplasms(gNEN); endoscopy; clinical pathology
PACS:
R735.2
DOI:
10.3969/j.issn.1672-4992.2020.02.019
Abstract:
Objective:To investigate the clinical manifestations，endoscopic and pathological features of gastric neuroendocrine neoplasms (gNEN)．Methods:We retrospectively analyzed 40 patients with a pathological diagnosis of gNEN from January 2014 to January 2016.Their clinical presentation,endoscopic features,microscope and tissue morphology,and treatment were reviewed.Results:One of the 40 cases was accompanied by clinical features of carcinoid Syndrome.The other patients were with nonspecific symptoms of digestive tract.The lesions were more often located on the gastric body(20/40，50%).There were 17 cases of neuroendocrine tumor(NET)，22 cases of neuroendocrine carcinoma(NEC)，1 case of mixed adenocarcinoma(MANEC)．The positive rates of Syn and CgA were 95.0% and 62.5%,and the differences were statistical significance (P＜0.05).Seventeen cases were type I gNEN,three cases were type II,and twenty cases were type III.Thirteen subjects were treated only with endoscopic mucosal resection (EMR) or endoscopic submucosal dissection(ESD).A partial or total gastrectomy was done in twenty-four patients，and eighteen cases of which were followed by adjuvant chemotherapy.Three cases had distant metastasis when diagnosed,only palliative treatment was administered.Conclusions:The incidence of gNEN was increased greatly in recent years.Clinicians should be familiar with clinical pathological features and endoscopic characteristics of this disease surgical treatment or EMR/ESD depending on the extension of the disease.Early diagnosis and individual treatment is very important for the patients.Correct early diagnosis is attainable by using endoscopy,histopathologic characteristics,and should precede any treatment.

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河南省医学科技攻关计划项目（编号：201702145）
Last Update: 2019-11-29