|Table of Contents|

Expression and clinical significance of Fascin protein in lung adenocarcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 02
Page:
236-239
Research Field:
Publishing date:

Info

Title:
Expression and clinical significance of Fascin protein in lung adenocarcinoma
Author(s):
Zhao Qing; Ni Zexu; Zheng Jinhua; Wang Jianwen
Department　of　Pathology,Tungwah Hospital of Sun Yat-sen University,Guangdong Dongguan 523110,China.
Keywords:
Fascin protein; lung adenocarcinoma; immunohistochemistry; prognosis
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.02.013
Abstract:
Objective:To study the expression of Fascin protein in lung adenocarcinoma and its relationship with clinical pathological characteristics.Methods:Immunohistochemical method applied to 75 lung adenocarcinoma tissues was performed to examine the expression status of Fascin and their impacts on the prognosis and other pathologic parameters.Results:High expression of Fascin was tested in 21 cases (28.0%).Accordingly,the high expression of Fascin was significantly associated with lymph node metastasis (P＜0.05),advanced pTNM stage (P＜0.01) and tumor progression (P＜0.01).Poor overall survival and progression-free survival were observed in patients with high expression of Fascin protein (P＜0.05).The Cox multivariate survival analysis showed that high expression of Fascin was independent prognostic factor (P＜0.05).Conclusion:High expression of Fascin correlates with poor outcome in lung adenocarcinoma patients.Accordingly,Fascin protein may be attractive therapeutic strategies and molecular prognosis marker for lung adenocarcinoma patients in future clinical trials.

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Last Update: 2019-11-29