|Table of Contents|

Immune mechanism of intestinal microecological balance in the treatment of non-small cell lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2020 01
Page:
13-16
Research Field:
Publishing date:

Info

Title:
Immune mechanism of intestinal microecological balance in the treatment of non-small cell lung cancer
Author(s):
Geng Zhiguang1Wang Yongfeng2
1.Department of Respiratory Medicine,People’s Hospital of Yishui County,Shandong Linyi 276400,China;2.Department of Respiratory Medicine,Linyi Central Hospital,Shandong Linyi 276400,China.
Keywords:
non-small cell lung cancerLactobacilluscisplatin
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2020.01.004
Abstract:
Objective:To explore the immune mechanism of intestinal microecological balance in the treatment of non-small cell lung cancer.Methods:72 mice with Lewis lung cancer were divided into control group,cisplatin group,cisplatin/antibiotic group and cisplatin/Lactobacillus group.The tumor volume and survival time of each group were recorded,and the expression of related oncoproteins and serum cytokines were detected.Results:Compared with the control group,tumor growth in other groups was significantly inhibited.Compared with cisplatin/Lactobacillus group,the survival time of cisplatin group and cisplatin/antibiotic group was significantly shorter.Compared with the control group,the expression level of oncogene VEGFA and Ras in cisplatin group decreased by 47.9% and 33.2% respectively,and the expression level of Bax and CDKNIB of tumor suppressor gene was increased with 121.7% and 128.9% respectively.The results of ELISA detection showed that compared with cisplatin/antibiotic group,the level of IL-6 and IFN-gamma in cisplatin/Lactobacillus group increased significantly,and the level of IL-10 decreased significantly,but there was no significant difference in TNF-alpha.Compared with the control group,the number of 4 bacteria groups in cisplatin group showed a decreasing trend,and the number of 4 species of cisplatin/antibiotic group decreased most significantly,and the number of cisplatin/Lactobacillus group was almost close to that of the control group.Conclusion:Intestinal microecological balance can help lung cancer and enhance the antitumor effect of cisplatin.

References:

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