|Table of Contents|

The molecular mechanism and organ-specificity of breast cancer metastasis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
685-688
Research Field:
Publishing date:

Info

Title:
The molecular mechanism and organ-specificity of breast cancer metastasis
Author(s):
Guo Jixue; Kang Xinmei; Zhang Qingyuan
Department of Medical Oncology，The Affiliated Tumor Hospital of Harbin Medical University，Heilongjiang Harbin 150081，China.
Keywords:
breast cancer; metastasis; organotropism; mechanism
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2019.04.037
Abstract:
Although significant progress has been made in the treatment of local malignancies,there are still a considerable number of patients with metastasis.Metastasis is a complex,multistep biological process,involving a multitude of genes andbiomolecules.However,the understanding of the mechanism is still scattered,and we need to expand the study to improve the prevention and treatment of metastasis,thereby improving the survival of cancer patients.In order to improve long-term survival of cancer patients,it is essential to focus on prevention and treatment of metastatic disease and the specific steps of the transfer cascade,new approaches to eradicate metastatic foci,such as immunotherapy or targeted therapy,have been added to the current treatment.Or to prevent the spread of tumor cells to the two class organs and to interfere with the ability of the cancer cells to adapt to the new microenvironment,by blocking the secondary colonization and subsequent growth of the tumor cells through targeted transfer cascade and specific steps of organ specificity.In conclusion,the identification of tissue-specific signals during metastasis will pave the way for new therapeutic strategies.Here,we will review recent advances in this field,with special emphasis on the molecular mechanism and organ-specificity of breast cancer metastasis.

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黑龙江省教育厅科学技术研究项目（编号：12511z019）
Last Update: 1900-01-01