|Table of Contents|

The value of microRNA-29a in identifying of tuberculous and malignant pleural effusion and predicting the therapeutic efficacy of tuberculous pleural effusion

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
595-598
Research Field:
Publishing date:

Info

Title:
The value of microRNA-29a in identifying of tuberculous and malignant pleural effusion and predicting the therapeutic efficacy of tuberculous pleural effusion
Author(s):
Jiao Xin; Liu Ning
Department of Respiratory，Shenyang Chest Hospital，Liaoning Shenyang 110044，China.
Keywords:
microRNA-29a; tuberculous pleural effusion; malignant pleural effusion; differential diagnosis; efficacy predict
PACS:
R730.6
DOI:
10.3969/j.issn.1672-4992.2019.04.013
Abstract:
Objective:To investigate the value of microRNA-29a in identifying of tuberculous pleural effusion and malignant pleural effusion.To explore the predictive effect of microRNA-29a on the treatment results of tuberculous pleural effusion.Methods:A total of 48 cases of patients with tuberculous pleural effusion and 40 cases of patients with malignant pleural effusion treated in our hospital from March 2015 to March 2016 were included in the study.The mRNA of the blood,sputum and pleural effusion was extracted using Trizol.The expression of microRNA-29a was assessed by RT-PCR.Patients with tuberculous pleural effusion were treated with routine treatment (thoracentesis and 2HRZE/10HRE chemotherapy).The clinical curative effect reaction of the two groups were observed．The expression of microRNA-29a of serum was dynamic monitoring before and after the treatment.The relation between the expression of microRNA-29a and the clinical therapeutic efficacy was analyzed.Results:The blood and pleural effusion microRNA-29a of patients with tuberculous pleural effusion was significantly higher than patients with malignant pleural effusion (P＜0.05).But the sputum microRNA-29a had no significantly different between the two groups.The blood microRNA-29a was downregulated after the effective treatment of tuberculous pleural effusion.Conclusion:The expression of microRNA-29a in blood and pleural effusion could be used to identify of tuberculous and malignant pleural effusion.Dynamic monitoring the changes of serum microRNA-29a could predict the clinical efficacy of tuberculous pleural effusion.

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Memo

Memo:
辽宁省自然科学基金计划项目资助（编号：20170540995）
Last Update: 1900-01-01