|Table of Contents|

Effects of MTHFR polymorphism on breast cancer chemotherapeutic sensitivity

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 04
Page:
588-591
Research Field:
Publishing date:

Info

Title:
Effects of MTHFR polymorphism on breast cancer chemotherapeutic sensitivity
Author(s):
Hu Fengdi1; Yang Jilan1; Xie Lin1; Li Yang1; Long Tingfeng1; Shen Lida1; Zou Tianning2
1.Department of Medical Oncology；2.Department of Breast Surgery，The Third Affiliated Hospital of Kunming Medical University，Yunnan Province Tumor Hospital,Yunnan Kunming 650118,China.
Keywords:
breast cancer; methylenetetrahydrofolate reductase（MTHFR）; chemotherapy; genotype
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2019.04.011
Abstract:
Objective:To investigate the effects of MTHFR polymorphism on breast cancer chemotherapeutic sensitivity.Methods:104 breast cancer patients confirmed by pathology were treated with FEC regimen 2~6 cycles and DNA of peripheral blood was obtained．MTHFR genotypes were detected by PCR-RFLP.Patients with different genotypes were compared with the chemotherapeutic sensitivity.Results:Of the 104 patients,the frequencies of MTHFR C677T T/T,C/C and C/T genotype were 39(37.5%),55(52.9%) and 10(9.6%) respectively.Chemotherapeutic sensitivity of patients with T/T genotype was higher than C/C genotype and C/T genotype（P＜0.05）。The frequencies of MTHFR A1298C A/A,A/C and C/C genotype were 41(39.4%),56(53.8%) and 7(6.7%) respectively.There was no statistic significance in chemotherapeutic sensitivity and genotype（P＞0.05）．Conclusion:The present study indicates that polymorphisms of MTHFR may be an important clinical value to predict the breast cancer chemotherapeutic sensitivity.

References:

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Memo

Memo:
云南省教育厅科学研究基金项目(编号:2014Y162)；昆明医科大学应用基础研究联合专项资金项目(编号:2014FZ035)
Last Update: 1900-01-01