［1］Liebig C，Ayala G，Wilks JA，et al.Perineural invasion in cancer：A review of the literature［J］.Cancer，2009，115(15)：3379-3391.
［2］Amit M，Na'ara S，Gil Z.Mechanisms of cancer dissemination along nerves［J］.Nat Rev Cancer，2016，16(6)：399-408.
［3］Saloman JL，Albers KM，Li D，et al.Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer［J］.Proc Natl Acad Sci USA，2016，113(11)：3078-3083.
［4］Rodin AE，Larson DL，Roberts DK.Nature of the perineural space invaded by prostatic carcinoma［J］.Cancer，1967，20(10)：1772-1779.
［5］Batsakis JG.Nerves and neurotropic carcinomas［J］.Ann Otol Rhinol Laryngol，1985，94(4 Pt 1)：426-427.
［6］Scanlon CS，Banerjee R，Inglehart RC，et al.Galanin modulates the neural niche to favour perineural invasion in head and neck cancer［J］.Nat Commun，2015，6：6885.
［7］Ayala GE，Wheeler TM，Shine HD，et al.In vitro dorsal root ganglia and human prostate cell line interaction：Redefining perineural invasion in prostate cancer［J］.Prostate，2001，49(3)：213-223.
［8］Yang YH，Liu JB，Gui Y，et al.Relationship between autophagy and perineural invasion，clinicopathological features，and prognosis in pancreatic cancer［J］.World J Gastroenterol，2017，23(40)：7232-7241.
［9］Eibl G，Reber HA.A xenograft nude mouse model for perineural invasion and recurrence in pancreatic cancer［J］.Pancreas，2005，31(3)：258-262.
［10］Demir IE，Ceyhan GO，Rauch U，et al.The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity［J］.Neurogastroenterol Motil，2010，22(4)：480-490，e112-113.
［11］Chen W，Dong S，Zhou J，et al.Investigation of myoepithelial cell differentiation into schwann-like cells in salivary adenoid cystic carcinoma associated with perineural invasion［J］.Mol Med Rep，2012，6(4)：755-759.
［12］Entschladen F，Palm D，Niggemann B，et al.The cancer's nervous tooth：Considering the neuronal crosstalk within tumors［J］.Semin Cancer Biol，2008，18(3)：171-175.
［13］Demir IE，Boldis A，Pfitzinger PL，et al.Investigation of Schwann cells at neoplastic cell sites before the onset of cancer invasion［J］.J Natl Cancer Inst，2014，106(8)：184.
［14］Deborde S，Omelchenko T，Lyubchik A，et al.Schwann cells induce cancer cell dispersion and invasion［J］.J Clin Invest，2016，126(4)：1538-1554.
［15］Azam SH，Pecot CV.Cancer's got nerve：Schwann cells drive perineural invasion［J］.J Clin Invest，2016，126(4)：1242-1244.
［16］Shan C，Wei J，Hou R，et al.Schwann cells promote EMT and the Schwann-like differentiation of salivary adenoid cystic carcinoma cells via the BDNF/TrkB axis［J］.Oncol Rep，2016，35(1)：427-435.
［17］He S，Chen CH，Chernichenko N，et al.GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling［J］.Proc Natl Acad Sci USA，2014，111(19)：E2008-2E20017.
［18］Zhang Q，Cao DL，Zhang ZJ，et al.Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice［J］.J Neuroinflammation，2016，13(1)：183.
［19］Zhu Z，Zhang X，Guo H，et al.CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K/AKT pathway［J］.Mol Cell Biochem，2015，400(1-2)：287-295.
［20］Qi XW，Xia SH，Yin Y，et al.Expression features of CXCR5 and its ligand，CXCL13 associated with poor prognosis of advanced colorectal cancer［J］.Eur Rev Med Pharmacol Sci，2014，18(13)：1916-1924.
［21］He S，He S，Chen CH，et al.The chemokine (CCL2-CCR2)signaling axis mediates perineural invasion［J］.Mol Cancer Res，2015，13(2)：380-390.
［22］Demir IE，Kujundzic K，Pfitzinger PL，et al.Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells［J］.Proc Natl Acad Sci USA，2017，114(1)：E85-E94.
［23］Ben QW，Wang JC，Liu J，et al.Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinoma［J］.Ann Surg Oncol，2010，17(8)：2213-2221.
［24］Na'ara S，Gil Z，Amit M.Abstract 5072：Paracrine interactions between schwann cells and cancer cells promotes perineural invasion via L1cam secretion［J］.Cancer Res，2016，76(14 Supplement)：5072.
［25］Swanson BJ，McDermott KM，Singh PK，et al.MUC1 is a counter-receptor for myelin-associated glycoprotein(Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion［J］.Cancer Res，2007，67(21)：10222-10229.
［26］Togami S，Nomoto M，Higashi M，et al.Expression of mucin antigens(MUC1 and MUC16) as a prognostic factor for mucinous adenocarcinoma of the uterine cervix［J］.J Obstet Gynaecol Res，2010，36(3)：588-597.
［27］Magnon C，Hall SJ，Lin J，et al.Autonomic nerve development contributes to prostate cancer progression［J］.Science，2013，341(6142)：1236361.
［28］Zhao CM，Hayakawa Y，Kodama Y，et al.Denervation suppresses gastric tumorigenesis［J］.Sci Transl Med，2014，6(250)：250ra115.
［29］Ghilardi JR，Freeman KT，Jimenez-Andrade JM，et al.Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting，neuroma formation and bone cancer pain［J］.Mol Pain，2010，6：87.
［30］Horowitz M，Neeman E，Sharon E，et al.Exploiting the critical perioperative period to improve long-term cancer outcomes［J］.Nat Rev Clin Oncol，2015，12(4)：213-226.