|Table of Contents|

Clinical efficacy of MRI image-based three-dimensional brachytherapy in locally advanced cervical cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 03
Page:
456-459
Research Field:
Publishing date:

Info

Title:
Clinical efficacy of MRI image-based three-dimensional brachytherapy in locally advanced cervical cancer
Author(s):
Li Zhiru1; Li Chao2; Huang Yecai3; Zeng Shouqun1; Lang Jinyi3
1.Department of Oncology；2.Department of Obstetrics and Gynecology,Chengdu Fifth People's Hospital，Sichuan Chengdu 611130，China； 3.Department of Radiotherapy，Sichuan Cancer Hospital，Sichuan Chengdu 610041，China.
Keywords:
cervical cancer; IMRT; MRI; three-dimensional brachytherapy
PACS:
R737.33
DOI:
10.3969/j.issn.1672-4992.2019.03.024
Abstract:
Objective：To analyze the clinical efficacy and adverse reactions of IMRT combined with chemotherapy and MRI image-based intracavitary brachytherapy in locally advanced cervical cancer.Methods：126 cervical cancer patients (FIGO staging：Ⅱb-Ⅳa) were prospectively analyzed in Sichuan Cancer Hospital and Chengdu Fifth People's Hospital from January,2014 to February,2017.All patients received IMRT external beam radiotherapy and MRI image based high dose rate of three-dimensional brachytherapy.Each brachytherapy required perfect CT and (or) MRI image scanning，and at least 2 MRI scans were performed.The high-risk clinical target volume (HR-CTV)and organs at risks (OARs) were defined according to the GEC-ESTRO standards.HR-CTV prescription dose reached 80~85 Gy (EQD2)，with concomitant chemoradiotherapy of cisplatin.CTCAE and RTOG criteria were used to evaluate the adverse reactions.The Kaplan-Meier method was used for survival analyses.Results：The average EQD2 of the target region GTV,HR-CTV,and IR-CTV D90 were 91.7 (81.8~107.8) Gy,81.7 (77.8~89.9) Gy,72.0 (70.8~75.1) Gy (α/β=10) respectively. The V100 of 100% prescription dose corresponding to HR-CTV and IR-CTV was 92.6% (89.9%~97.4%) and 92.8% (88.5%~96.8%) respectively.Three-year follow-up data showed that the local control rate (LC)，disease-free survival rate (DFS)，overall survival rate (OS) were 89.5%，78.2% and 80.9% respectively.The toxicity incidences of chronic gastrointestinal tract (GI) and genitourinary system (GU)in grade Ⅲ were 2.5% and 5.8% respectively，and there was no grade Ⅳ toxicity.Conclusion：IMRT combined with chemotherapy and MRI image-based intracavitary brachytherapy in locally advanced cervical cancer showed a better outcome and tolerable side effects.

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Last Update: 2018-12-29