|Table of Contents|

A comparative analysis of the efficacy and prognosis of different radiotherapy for multiple brain metastases(≥4)

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2019 01
Page:
41-45
Research Field:
Publishing date:

Info

Title:
A comparative analysis of the efficacy and prognosis of different radiotherapy for multiple brain metastases(≥4)
Author(s):
Shen Anqi1; Qian Jing1; Zhang Longzhen2; Li Zhongxi2; Huang Long2; Liu Guihong2
1.Department of Oncology，the Graduate School,Xuzhou Medical University,Jiangsu Xuzhou 221002,China;2.Department of Radiation Oncology，the Affiliated Hospital of Xuzhou Medical University，Jiangsu Xuzhou 221002，China.
Keywords:
brain metastases; stereotactic radiosurgery; whole brain radiotherapy with simultaneous integrated boost; efficacy; prognosis
PACS:
R739.41
DOI:
10.3969/j.issn.1672-4992.2019.01.010
Abstract:
Objective：To investigate the efficacy and prognosis of stereotactic radiosurgery(SRS) alone and whole brain radiotherapy with simultaneous integrated boost(WBRT-SIB) for multiple brain metastases(≥4).Methods：A retrospective analysis was performed among 93 patients with multiple brain metastases(≥4) who were admitted to our hospital and had completed follow-up data from February 2012 to May 2017.The initial treatment for 48 cases was SRS alone，and for other 45 cases was WBRT-SIB.The therapeutic effect，neurological complications were compared between the two groups and the factors impacting prognosis were analysed.Results：The local control rate for six months were 83.3% in SRS alone group and 62.2% in WBRT-SIB group(P=0.034).The median intracranial progression free survival(iPFS) in WBRT-SIB group was significantly higher than that in SRS alone group (P=0.005).There were no significant differences in the median survival time between SRS alone group and WBRT-SIB group(P=0.492).The incidence of neurological complications in the WBRT-SIB group was higher than that in SRS group，and the difference was statistically significant(P=0.020).The univariate and Cox multivariate analyses showed that the absence of extracranial metastases，the Karnofsky performance score(KPS)>70，and the total target volume<10 cm3 were associated with improved survival(P<0.05，respectively).Conclusion：SRS alone and WBRT-SIB achieve similar treatment outcomes in patients with multiple brain metastases(≥4).SRS alone can be used as an effective and less toxic initial treatment for this multiple brain metastases(≥4).

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Memo

Memo:
国家重点研发计划项目（编号：2017YFC0113700）；江苏省卫生厅科技项目（编号：H201426）；徐州市科技局项目（编号：KC16SH065）
Last Update: 2018-11-30