|Table of Contents|

Efficacy and safety of endostar combined with gemcitabine and docetaxel in advanced soft tissue sarcomas

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 05
Page:
769-772
Research Field:
Publishing date:

Info

Title:
Efficacy and safety of endostar combined with gemcitabine and docetaxel in advanced soft tissue sarcomas
Author(s):
Zhang DianbaoKang YixinGuo Yanzhen
Department of Medical Oncology,the First Affiliated Hospital of Henan University of Science and Technology,Henan Luoyang 471003,China.
Keywords:
endostaradvanced soft tissue sarcomachemotherapy
PACS:
R738.6
DOI:
10.3969/j.issn.1672-4992.2018.05.030
Abstract:
Objective:To investigate the efficacy and safety of endostar combined with gemcitabine and docetaxel (GD) in advanced soft tissue sarcomas.Methods:49 patients with advanced soft tissue sarcomas from January 2013 to April 2016 in our hospital were randomly divided into endostar group (endostar combined with gemcitabine and docetaxel) and control group (gemcitabine combined with docetaxel).Two groups of patients' disease control rates,objective response rates,adverse reaction and progression-free survival were compared.Results:In endostar group and the control group,disease control rates were 52.17% and 23.08% respectively (P<0.05) and objective response rates were 17.39% and 3.85% respectively (P>0.05).There was no statistically significant difference between two groups of patients with grade Ⅲ and Ⅳ adverse reactions.Progression-free survial was (4.08±0.70) months and (2.35±0.29) months in endostar group and control group,and the difference was statistically significant (P<0.05).Conclusion:Endostar combined GD regimen has better curative effect than GD regimen,and has good tolerance in advanced soft tissue sarcomas.

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