|Table of Contents|

Expressions and clinical significance of STAT3 and VEGF in lung squamous cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 05
Page:
705-708
Research Field:
Publishing date:

Info

Title:
Expressions and clinical significance of STAT3 and VEGF in lung squamous cell carcinoma
Author(s):
Wang Yan1Chen Yumin1Li Jiaojiao2
1.Department of Cardiothoracic Surgery;2.Department of ICU,Renmin Hospital,Hubei University of Medicine,Hubei Shiyan 442000, China.
Keywords:
STAT3VEGFlung squamous cell carcinomaimmunohistochemistry
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2018.05.014
Abstract:
Objective:To investigate the expressions of STAT3 and VEGF in lung squamous cell carcinoma and its relationships with clinical pathological characteristics.Methods:The expressions of STAT3 and VEGF protein were examined by immunohistochemistry in the data of 60 cases of lung squamous cell carcinoma and 30 cases normal lung tissue.To analyze clinical pathological characteristics.Results:The positive expression rates of STAT3 in normal lung tissue and lung squamous cell carcinoma were 33.3% and 56.7%,the positive expression rates of VEGF were 23.3% and 80%.The expression of STAT3 in lung squamous cell carcinoma patients was significantly related to the depth of invasion,lymph node metastasis and TNM stage(P<0.05).And it wasn' t significantly related to its gender,age and tumor cell differentiation degree.Conclusion:High expressions of STAT3 and VEGF were related to carcinogenesis and development of lung squamous cell carcinoma.They may contribute to judgment of invasion and metastasis.

References:

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