|Table of Contents|

Expression of miRNA-143 in esophageal squamous cell cancer and clinical significance

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 05
Page:
695-698
Research Field:
Publishing date:

Info

Title:
Expression of miRNA-143 in esophageal squamous cell cancer and clinical significance
Author(s):
Huang Tao1; Zhou Bin2; Liu Weiliang1; Wang Yong1; Xu Jianhua1; Zhang Wei1
1.Hanzhoung 3201 Hospital Affiliated to Medical College of Xi'an Jiaotong University，Shaanxi Hanzhong 723000，China；2.The Second Affiliated Hospital of Xi'an Jiaotong University Medical College，Shaanxi Xi'an 710004，China.
Keywords:
miRNA-143; esophageal squamous cell carcinoma(ESCC); Real time-PCR
PACS:
R735.1
DOI:
10.3969/j.issn.1672-4992.2018.05.011
Abstract:
Objective：To analyze the relationship of miRNA-143 expression quantity in the esophageal squamous cell carcinoma(ESCC) and their pathological features.Methods：Adopting the Real time-PCR method to detect 60 cases of ESCC tissues and the expression quantity of normal esophageal tissue of the miRNA-143，also analyze the relationship between their expression quantity and clinical pathological features.Results：The miRNA-143 expression quantity is lower than the near normal esophageal tissue quantity in the ESCC.The miRNA-143 expression quantity is obviously（P<0.05）related to tumor stage，lymph node metastasis.No correlation (P>0.05) with the patients age，gender，tumor location and degree of tumor differentiation.The area under ROC curve was 0.875，and the sensitivity and specificity of diagonsis were 86.5% and 82.8% of miRNA-143.Conclusion：In the tumor tissue of the ESCC patients，the miRNA-143 expression quantity is obviously declined，and its expression is obviously.miRNA-143 may be one of the potential tumor markers of ESCC.

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Memo

Memo:
西安交通大学医学院附属汉中3201医院院科研基金（编号：3201YK201509）
Last Update: 1900-01-01