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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2018 05

Page:

685-690

Research Field:

Publishing date:

Info

Title:

The effect of polysaccharide on the STAT3 pathway associated biochemical markers was observed in the treatment of patients with nasopharyngeal carcinoma

Author(s):

Li Zhe¹; Liu Shujia¹; Chen Jinjie¹; Zhao Yi²; Weng Yuling³

1.Dongguan Wanjiang Hospital,Guangdong Dongguan 523500,China;2.Guangdong Medical University,Guangdong Dongguan 523808,China;3.Dongguan People's Hospital,Guangdong Dongguan 523000，China.

Keywords:

ripe yellow polysaccharide; nasopharyngeal carcinoma; STAT3 pathway; proinflammatory factor

PACS:

R739.63

DOI:

10.3969/j.issn.1672-4992.2018.05.009

Abstract:

Objective：To understand the specific effect of the patients on the STAT3 pathway of the statin and the related protein content.Methods：Were retrospectively analyzed from February 2015 to November，2016，132 patients with nasopharyngeal carcinoma.The control group with 66 patients underwent chemoradiation therapy，on the basis of control，the experimental group(66 cases) received the ehmannia glutinosa polysaccharide of the pills.Compare two groups of patients in early treatment，treatment for 15 days，30 days，60 days treatment with proinflammatory factor （TNF-α，IL-6，IL-1β，IL-8） and the STAT3 pathway related protein （NF-κB p65 protein，P-STAT3 protein） content differences.Results：At different time，the experimental group of TNF-α，IL-6，IL-1β，IL-8，NF-κB p65 protein and P-STAT3 proteins and the control group the TNF-α，IL-6，IL-8，NF-κB p65 protein and P-STAT3，had statistically significant differences.The difference of clinical therapeutic effect between the two groups was statistically significant（P<0.05），and the total relief and partial remission of patients in the experimental group were more than that of the control group.In 0 day，the proinflammatory factor and STAT3 pathway related protein content differences had no statistical significance （P>0.05），In 15th day，30th day，60th day，the content of proinflammatory factor differences were statistically significant （both P<0.05）.The proinflammatory factor （TNF-α，IL-6，IL-1β，IL-8） and STAT3 pathway related protein （NF-κB p65 protein，P-STAT3 protein） content received repetitive measure analysis of variance，and their differences consisted of categories，time，category and the time of the interaction.Conclusion：Based on the concurrent chemoradiotherapy，patients with nasopharyngeal carcinoma gives rehmannia glutinosa polysaccharide the pills，STAT3 pathway in patients with nasopharyngeal carcinoma have a significant impact，so as to significantly improve the patient's body and proinflammatory factor related protein expression of specific amount.

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Memo

Memo:

广东省中医药局科研基金项目（编号：2162164）；广东省自然科学基金项目（编号：2015A030310046）

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