|Table of Contents|

The expression of PEG3 gene in clear cell renal cell carcinoma and its prognostic significance basing on data mining

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 04
Page:
548-553
Research Field:
Publishing date:

Info

Title:
The expression of PEG3 gene in clear cell renal cell carcinoma and its prognostic significance basing on data mining
Author(s):
Chen ZhanCui QiangQi ChuangZhao HuZhu HehuanLu JunTan Jianming
Xiamen University,Fuzhou General Hospital,Fujian Provincial Key Laboratory of Transplant Biology,Fujian Fuzhou 350025,China.
Keywords:
PEG3clear cell renal cell carcinomadatabase analysismethylation
PACS:
R737.11
DOI:
10.3969/j.issn.1672-4992.2018.04.016
Abstract:
Objective:To explore the expression and significance of imprinted gene PEG3 in clear cell renal cell carcinoma.Methods:The expression of PEG3 in clear cell renal cell carcinoma was mined in Oncomine database and GEPIA.The correlation between PEG3 and the survival time of patients with clear cell renal cell carcinoma was analyzed by KM-Plotter.The methylation level of PEG3 promoter region was used by MethHC,and the PEG3 - interacting proteins were analyzed by String-DB database.The expression of PEG3 protein in normal renal tissue and clear cell renal cell carcinoma was detected by Human Protein Atlas.Results:At the mRNA level,PEG3 was lower in clear cell renal cell carcinoma than normal renal tissue,and the expression level was negatively correlated with the prognosis of renal cell carcinoma (Log-rank P=0.001 1),the expression of PEG3 protein in clear cell renal cell carcinoma was also lower than that in normal renal tissue.The methylation of PEG3 promoter in clear cell renal cell carcinoma was increased.PEG3 related proteins are NLRP7,MEST,SIAH1,PEG10,CDC25B,etc,may be involved in cell mitotic regulation and genetic imprinting and other cellular functions.Conclusion:PEG3 was decreased in clear cell renal cell carcinoma and was related to the patients' survival,it would be an important theoretical support for the further research.

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Memo

Memo:
National Natural Science Foundation of China(No.81570748,81370948);国家自然科学基金(编号:81570748,81370948)
Last Update: 2017-12-29