|Table of Contents|

Progress in research on anti - tumor effect of MDA 7/IL-24

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 02
Page:
321-324
Research Field:
Publishing date:

Info

Title:
Progress in research on anti - tumor effect of MDA 7/IL-24
Author(s):
Cao Hongdan
Chongqing Medical and Pharmaceutical Higher Specialty College,Chongqing 401331,China.
Keywords:
MDA 7/IL-24tumorinhibition
PACS:
R730.59
DOI:
10.3969/j.issn.1672-4992.2018.02.041
Abstract:
The melanoma differentiation related gene (melonoma differentiation associated gene 7,MDA 7) was isolated from human melanoma cells by subtractive hybridization.Since its molecular biological characteristics are similar to that of IL-10,it was classified as IL-10 family,and was named IL-24.MDA 7 / IL-24 has a wide range of anti-tumor biological effects.It can produce growth inhibition of many tumor cells through a variety of ways.The mechanism involved in anti-tumor was related to apoptosis induction,autophagy,inhibition of tumor revascularization and invasion and metastasis,immune regulation.As a cytokine with multiple antitumor effects,MDA 7/IL-24 has been shown to be a good therapeutic effect in clinical stage I trials and was known as the "magic bullet" for cancer treatment.In this paper,we review the role of MDA 7/IL-24 in tumor therapy and its mechanism,which will provide reference for the study of MDA 7/IL-24 in tumor gene therapy.

References:

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Memo:
重庆市卫生计生委医学科研项目(编号:2016MSXM105)
Last Update: 2017-11-30