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Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:

2018 02

Page:

314-317

Research Field:

Publishing date:

Info

Title:

Inhibitors of JAK/STAT signaling pathway and lung cancer

Author(s):

Gu Lei¹; Zhang Lijun²; Liu Lifang¹; Hu Dan¹; Liang Wentong¹

1.The First Hospital of Baoding,Hebei Baoding 071000,China£»2.Graduate School of Chengde Medical College,Hebei Chengde 067000,China.

Keywords:

JAK/STAT signal pathway; lung cancer; targeting therapy

PACS:

R734.2

DOI:

10.3969/j.issn.1672-4992.2018.02.039

Abstract:

The Janus kinase/signal transducer and activator of transcriptions signaling pathway is the important signal transduction pathways which is widely involved in cell proliferation,differentiation,apoptosis,and inflammation and other processes.It can be regulated by negative regulatory factors,interaction with other signaling pathways,STATs covalent modification and other ways.Activation of JAK/ STAT pathway promotes the development of various diseases including various solid tumors,lymphoma,leukemia and inflammatory diseases and others.The study of JAK/STAT signaling pathway and the inhibitors of JAK/STAT signaling pathway is helpful for the prevention and treatment of lung cancer.This article focuses on the relationshop of JAK/STAT signaling pathway and lung cancer and targeting therapy for the JAK/STAT signaling pathway.

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