|Table of Contents|

Carvacrol suppresses the expression of ADAM9 in human oral squamous cell carcinoma

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2018 02
Page:
170-173
Research Field:
Publishing date:

Info

Title:
Carvacrol suppresses the expression of ADAM9 in human oral squamous cell carcinoma
Author(s):
Shi Xinqi1; Lu Hao1; Sun Honghao1; Bao Yiwen2; Gong Yawei2; Li Yanshu3
1.Major of Clinical Medicine,Seven-year Program;2.Major of Clinical Medicine,China Medical University,Liaoning Shenyang 110122,China;3.Department of Cell Biology,Key Laboratory of Cell Biology,National Health and Family Planning Commission of the PRC,and Key Laboratory of Medical Cell Biology,Ministry of Education of the PRC,China Medical University,Liaoning Shenyang 110122,China.
Keywords:
carvacrol; oral squamous cell carcinoma; ADAM9
PACS:
R739.8
DOI:
10.3969/j.issn.1672-4992.2018.02.003
Abstract:
Objective:To investigate the effect of carvacrol on a disintegrin and metalloprotease 9 (ADAM9) expression in human oral squamous cell carcinoma (OSCC).Methods:Western blot analysis was used to detect the ADAM9 expression of in OSCC (UM-SCC-23 and Tca-8113)-carvacrol treated cell lines.UM-SCC-23 and Tca-8113 cells were exposed to vehicle alone as control or 40 μmol/L carvacrol for 24 h,then cells were harvested and total RNA were extracted.The ADAM9 level were measured with real-time reverse-transcription polymerase chain reaction (RT-PCR).Results:Carvacrol significantly inhibited the expression of ADAM9 in OSCC cell lines.Conclusion:These results provide novel insights into the mechanism of carvacrol and suggest potential therapeutic strategies for human OSCC.

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Memo

Memo:
National Natural Science Foundation of China（No.31401115）；国家自然科学基金资助项目（编号：31401115）；辽宁省科学技术基金（编号：2015020528）
Last Update: 2017-11-30