|Table of Contents|

Research progress of vasculogenic mimicry and its influencing factors in cervical cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

2017 10
Research Field:
Publishing date:


Research progress of vasculogenic mimicry and its influencing factors in cervical cancer
Chen Yu1Wang Zhenguo2Li Zheng1
1.Hebei North University,Hebei Zhangjiakou 075000,China;2.Department of Obstetrics and Gynecology,309th Hospital,PLA,Beijing 100091,China.
vasculogenic mimicryhypoxiaepithelial-mesenchymal transitioncancer stem cellscervical cancer
Vasculogenic mimicry (VM),as a new type of endotheliocyte-independent blood supply model of tumor,has been concerned recently.Many factors,such as hypoxia,epithelial-mesenchymal transition (EMT) and the existence of cancer stem cells (CSCs) play important roles in the VM formation and tumor,including cervical cancer.It can provide new ideas for the treatment of recurrence and metastasis of cervical cancer through studying the mechanisms of VM and its influencing factors in cervical cancer progression.


[1] Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.
[2] Alam MS,Ali A,Mehdi SJ,et al.HPV typing and its relation with apoptosis in cervical carcinoma from Indian population[J].Tumour Biol,2012,33(1):17-22.
[3] Rughooputh S,Manraj S,Eddoo R,et al.Expression of the c-myc oncogene and the presence of HPV 18:possible surrogate markers for cervical cancer[J]?Br J Biomed Sci,2009,66(2):74-78.
[4] Qureshi R,Arora H,Rizvi MA.EMT in cervical cancer:Its role in tumour progression and response to therapy[J].Cancer Lett,2015,356(2):321-331.
[5] Kerbel RS.Reappraising antiangiogenic therapy for breast cancer[J].Breast,2011,20(Suppl 3):S56-S60.
[6] Maniotis AJ,Folberg R,Hess A,et al.Vascular channel formation by human melanoma cells in vivo and in vitro:vasculogenic mimicry[J].Am J Pathol,1999,155(3):739-752.
[7] Ren K,Lu X,Huang WQ,et al.Manifestation of vasculogenic mimicry in osteosarcoma and its prognostic significance[J]? Chin Clin Oncol,2015,20(3):238-243.[任可,陆晓,黄伟谦,等.骨肉瘤组织中血管生成拟态的表现及预后意义[J].临床肿瘤学杂志,2015,20(3):238-243.]
[8] Fan YL,Zheng M,Tang YL,et al.A new perspective of vasculogenic mimicry:EMT and cancer stem cells[J].Oncol Lett,2013,6(5):1174-1180.
[9] Liu Z,Sun B,Qi L,et al.Zinc finger E-box binding homeobox 1 promotes vasculogenic mimicry in colorectal cancer through induction of epithelial-to-mesenchymal transition[J].Cancer Sci,2012,103(4):813-820.
[10] Wang BB,Wu SW,Cheng ZN.Detection of vasculogenic mimicry in cervical squamous cell carcinomas and its prognostic significance[J].J Prac Med,2014,30(19):3111-3113.[王蓓蓓,武世伍,承泽农.宫颈鳞癌中血管生成拟态检测及其临床意义[J].实用医学杂志,2014,30(19):3111-3113.]
[11] Cui Y,Li SS.Hypoxia,epithelia-mesenchymal transition in carcinoma[J].Chin J Pathol,2014,43(3):203-206.[崔瑶,李珊珊.缺氧、上皮间质转化与肿瘤[J].中华病理学杂志,2014,43(3):203-206.]
[12] Mayer A,Hockel M,Schlischewsky N,et al.Lacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix[J].Br J Cancer,2013,108(2):402-408.
[13] Huang M,Chen Q,Xiao J,et al.Overexpression of hypoxia-inducible factor-1a is a predictor of poor prognosis in cervical cancer[J].Int J Gynecol Cancer,2014,24(6):1054-1064.
[14] Huang XH,Xiang L,Gong L,et al.Vasculogenic mimicry in cervical squamous cell carcinoma tissues and the expression of HIF-1α[J].J Mod Med Health,2015,31(5):645-650.[黄小环,向丽,龚莉,等.宫颈鳞癌组织中血管生成拟态及HIF-1α的表达[J].现代医药卫生,2015,31(5):645-650.]
[15] Zhang YZ,Yu WW,Song EL.Vasculogenic mimicry and EphA2 expression in cervical squamous cell carcinoma and their significances[J].Maternal & Child Health Care of China,201l,26(5):742-743.[张一真,俞薇薇,宋恩霖.子宫颈鳞状细胞癌组织中血管生成拟态和EphA2的表达及意义[J].中国妇幼保健,201l,26(5):742-743.]
[16] Le XF,Sun BJ,Guo SX,et al.Status and prospect of vasculogenic mimicry in cancer research[J].Modern Oncology,2014,22(9):2204-2208.[乐晓峰,孙彬佳,郭斯翊,等.血管生成拟态在肿瘤研究中的现状与展望[J].现代肿瘤医学,2014,22(9):2204-2208.]
[17] Paulis YW,Soetekouw PM,Verheul HM,et al.Signalling pathways in vasculogenic mimicry[J].Biochim Biophys Acta,2010,1806(1):18-28.
[18] El Hallani S,Boisselier B,Peglion F,et al.A new alternative mechanism in glioblastoma vascularization:tubular vasculogenic mimicry[J].Brain,2010,133(Pt4):973-982.
[19] Wang W,Lin P,Sun B,et al.Epithelial-mesenchymal transition regulated by EphA2 contributes to vasculogenic mimicry formation of head and neck squamous cell carcinoma[J].Biomed Res Int,2014,2014:803914.
[20] Ma JL,Han SX,Zhu Q,et al.Role of Twist in vasculogenic mimicry formation in hypoxic hepatocellular carcinoma cells in vitro[J].Biochem Biophys Res Commun,2011,408(4):686-691.
[21] Hendrix MJ,Seftor EA,Hess AR,et al.Vasculogenic mimicry and tumour-cell plasticity:lessons from melanoma[J].Nat Rev Cancer,2003,3(6):411-421.
[22] Cheng Y,Zhou Y,Jiang W,et al.Significance of E-cadherin,β-catenin,and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma[J].Hum Pathol,2012,43(8):1213-1220.
[23] Wan HY,Li QQ,Zhang Y,et al.MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells[J].Cancer Lett,2014,355(1):148-158.
[24] Yang X,Li S,Li W,et al.Inactivation of lysyl oxidase by beta-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells[J].Oncol Rep,2013,29(2):541-548.
[25]Lu CH,Sheng XG.Research progress of cervical carcinoma associated stem cells[J].Chin J Cancer Prev Treat,2013,20(4):317-320.[路春华,盛修贵.宫颈癌相关干细胞的研究进展[J].中华肿瘤防治杂志,2013,20(4):317-320.]
[26] Lopez J,Poitevin A,Mendoza-Martinez V,et al.Cancer- initiating cells dedrived from established cervical cell lines exhibit stem-cell markers and increased radioresistance[J].BMC Cancer,2012,12:48.
[27] Li J,Zhou BP.Activation of beta-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters[J].BMC Cancer,2012,11:49.
[28] Gu W,Yeo E,McMillan N,et al.Silencing oncogene expression in cervical cancer stem-like cells inhibits their cell growth and self-renewal ability[J].Cancer Gene Ther,2012,18(12):897-950.
[29] Du J,Sun B,Zhao X,et al.Hypoxia promotes vasculogenic mimicry formation by inducing epithelial-mesenchymal transition in ovarian carcinoma[J].Gynecol Oncol,2014,133(3):575-583.
[30] Sun D,Sun B,Liu T,et al.Slug promoted vasculogenic mimicry in hepatocellular carcinoma[J].J Cell Mol Med,2013,17(8):1038-1047.
[31] Zhang D,Sun B,Zhao X,et al.Twist1 expression induced by sunitinib accelerates tumor cell vasculogenic mimicry by increasing the population of CD133+ cells in triple-negative breast cancer[J].Mol Cancer,2014,13:207.
[32] Zhang S,Guo H,Zhang D,et al.Microcirculation patterns in different stages of melanoma growth[J].Oncol Rep,2006,15(1):15-20.


Last Update: 2017-04-01