|Table of Contents|

Research progress on the role of RBP-Jκ in KSHV replication

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 06
Page:
975-978
Research Field:
Publishing date:

Info

Title:
Research progress on the role of RBP-Jκ in KSHV replication
Author(s):
Qi YanTan XiaohuaZhou TongNiu WanqiangYang Lei
School of Medicine,Hangzhou Normal University,Zhejiang Hangzhou 310036,China.
Keywords:
KSHVRTALANARBP-Jκ
PACS:
R730.231
DOI:
10.3969/j.issn.1672-4992.2017.06.039
Abstract:
Kaposi's sarcoma-associated herpesvirus (KSHV),also known as human herpesvirus 8,was closely associated with several malignancies,including Kaposi's sarcoma,primary effusion lymphoma,and multicentric Castleman's disease.KSHV had two alternative life cycle programs:Latent and lytic infection,but the mechanism was not fully understood.Present studies have suggested that replication and transcription activator (RTA) could promote the expression of multiple viral genes and reactivate virus to enter the lytic phase.RTA can also induce the expression of the latency-associated nuclear antigen (LANA).LANA,in turn,can repress transcription of RTA and maintain latency status.Recombination signal sequence binding protein Jκ (RBP-Jκ) is a major transcription repressor of the Notch signaling pathway.RBP-Jκ binding with RTA is essential for KSHV lytic reactivation,and,meanwhile induces the expression of LANA.RBP-Jκ also can bind with LANA,however,can repress the RTA transcription.In this paper,we reviewed the role of RBP-Jκ in KSHV replication.

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Memo

Memo:
国家自然科学基金(编号:81071636,81161120420)
Last Update: 2017-01-26