|Table of Contents|

δ-catenin,a member of p120ctn family,its research progress in several common malignant tumors

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 06
Page:
969-972
Research Field:
Publishing date:

Info

Title:
δ-catenin,a member of p120ctn family,its research progress in several common malignant tumors
Author(s):
Sun Lihong1Zhang Chaojun2Dong Caifeng2Zhang Jian3Zhang Junyi4
1.Department of Clinical Laboratory;2.Department of Respiratory Medicine;4.Department of Pathology,Affiliated Hospital of Chifeng University,Inner Mongolia Chifeng 024000,China;3.Department of Pathology,People's Hospital of Wuhai City,Inner Mongolia Wuhai 016000,China.
Keywords:
δ-cateninmalignant tumorsprognosis
PACS:
R730.7
DOI:
10.3969/j.issn.1672-4992.2017.06.037
Abstract:
As a member of cellular adhesion molecules-Catenin family,δ-catenin (also known as NPRAP,neural plakophilin-related armadillo protein),was expressed mainly in neurons at first,and δ-catenin also played important roles in maintains of structure and function in synapse.Accompanied by deeper research,the relationship between δ-catenin and malignant tumors attracted more and more attention of the researchers.Available results indicated that the expression of δ-catenin was increased in tumors and there had a significant correlation between δ-catenin overexpression and poor prognosis of patients with tumor.In this paper,the expression and clinical significant of δ-catenin were summarized in several common malignant tumors,including lung cancer,prostate cancer,breast cancer,esophagus cancer and colorectal cancer.Moreover,it also laid a foundation for next mechanism research of δ-catenin's promoting invasion and metastasis of tumors in this paper.

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Memo

Memo:
国家自然科学基金(编号:81201844);内蒙古自然科学基金(编号:2014MS0869);内蒙古卫计委医疗卫生科研计划项目(编号:201303156)
Last Update: 2017-01-26