|Table of Contents|

Correlation between triple-negative breast cancer and PARP1 expression:A Meta-analysis

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 06
Page:
893-896
Research Field:
Publishing date:

Info

Title:
Correlation between triple-negative breast cancer and PARP1 expression:A Meta-analysis
Author(s):
Zhang Xiuwei1Zhong Wen2Wei Shibo3Wen Jian4
1.Department of Pathology;2.Department of Radiotherapy;3.Department of Third General Surgery;4.Department of Fifth General Surgery,The Fourth Affiliated Hospital of China Medical University,Liaoning Shenyang 110032,China.
Keywords:
triple-negative breast cancerPARP1Meta-analysis
PACS:
R737.9
DOI:
10.3969/j.issn.1672-4992.2017.06.014
Abstract:
Objective:To evaluate the clinical correlation between PARP1 expression and triple-negative breast cancer.Methods:We searched PubMed,CNKI,Wanfang Database and other searches to collect literatures about the PARP1 expression in triple-negative breast cancer.Statistical analyses were carried out by using RevMan 5.2 software.Results:Five literatures of eligible studies involving 700 cases,which including 331 triple-negative breast cancer patients and 369 non triple-negative breast cancer patients,met the inclusion criteria.Results of the Meta-analysis showed that the expression of PARP1 in triple-negative breast cancer was significantly different from that of non triple-negative breast cancer (OR=3.24,95%CI:1.45~7.23,P=0.004).Conclusion:The expression of PARP1 was positively correlated with triple-negative breast cancer.It may be used as an indication to judge the prognosis of triple-negative breast cancer patients,but it still needs a large sample of randomized controlled trials for further study.Triple-negative breast cancer patients with conventional detection of PARP1 expression has some clinical significance.

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Memo

Memo:
辽宁省教育厅科学研究项目(编号:LK201604)
Last Update: 2017-01-26