|Table of Contents|

To predict postoperative progression by detection of PD-L1,Ki67 in patients with non-small cell lung cancer

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R]

Issue:
2017 06
Page:
885-889
Research Field:
Publishing date:

Info

Title:
To predict postoperative progression by detection of PD-L1,Ki67 in patients with non-small cell lung cancer
Author(s):
Liu Mingdong1; 2; Yu Zongyang2; Zhao Zhongquan2; Lei Zemin2; Ouyang Xuenong2
1.Department of Medical Oncology，Fuzhou Clinical College,the Second Military Medical University,Fujian Fuzhou 350000,China;2.Department of Medical Oncology,Fuzhou General Hospital of Nanjing Military Command,Fujian Fuzhou 350000,China.
Keywords:
PD-L1; Ki67; NSCLC; PFS
PACS:
R734.2
DOI:
10.3969/j.issn.1672-4992.2017.06.012
Abstract:
Objective:To investigate the co-relationship between PD-L1 and Ki67 expression and postoperative progression in patients with non-small cell lung cancer(NSCLC).Methods:Totally 94 cases of NSCLC were collected.The PD-L1 and Ki67 expression levels were detected in cancerous tissues by using immunohistochemistry.Results:PD-L1 positive expression was in 44 cases(46.81%) and the negative expression was in 50 cases(53.19%).The higher expression of Ki67 was in 33 cases(35.11%) and lower expression was in 61 cases(64.89%).The PD-L1 expression levels were related to and Ki67 expression（χ2 =8.05，P=0.01）.The progress-free survival(PFS) of the PD-L1 positive group was(21.86±2.93) months,the negative group was (35.69±3.08) months.There was a significant difference（χ2=10.60，P=0.00）.The PFS of Ki67 high expression was(21.01±2.76) months and the group of low expression is (33.11±2.92) months.There was a significantly difference too（χ2=5.69，P=0.02）.The level of PD-L1 expression is associated with tumor pathological type,tumor differentiation degree and postoperative progression（P＜0.05）.The Ki67 expression level is associated to gender,tumor pathological type and tumor differentiation degree（P＜0.05）.Multifactorial analysis results indicated that TNM staging,tumor differentiation degree and PD-L1 expression level are related to postoperative PFS statistically（P＜0.05）.Conclusion:The expression levels of PD-L1 and Ki67 in NSCLC tissue are related to the PFS.The more expression levels indicated that the shorter postoperative PFS.

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Memo

Memo:
福建省自然科学基金（编号：2016J01586 ）
Last Update: 2017-01-26